Reduce tremor stiffness and slowness
- Trial ID
- NCT05557864
- Official Title
- Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease; Udall Project 2 Aims 1 & 2
- Goal
- Reduce tremor stiffness and slowness
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University of Minnesota
- Study Type
- INTERVENTIONAL
- Enrollment
- 24 participants
- Conditions
- Parkinson's Disease
- Interventions
- Deep Brain Stimulation
Plain-Language Summary
The team wants to know whether the exact location of deep brain stimulation in the globus pallidus versus the subthalamic nucleus changes how much motor symptoms like tremor, stiffness, and slowness improve. They use the already implanted DBS devices to deliver continuous electrical pulses that modulate overactive brain circuits, they map electrode positions on high-resolution 7T MRI and relate location to motor benefit, and DBS can often reduce symptoms and sometimes allow lower levodopa doses or change medication response. Adults 21 to 89 with idiopathic Parkinson's who already have GP or STN DBS and existing 7T imaging are eligible, while people with major musculoskeletal or other neurologic disorders, dementia, or post-operative complications are excluded.
Locations
- University Of Minnesota, Minneapolis, Minnesota, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Deep Brain Stimulation. The team wants to know whether the exact location of deep brain stimulation in the globus pallidus versus the subthalamic nucleus changes how much motor symptoms like tremor, stiffness, and slowness improve. They use the already implanted DBS devices to deliver continuous electrical pulses that modulate overactive brain circuits, they map electrode positions on high-resolution 7T MRI and relate location to motor benefit, and DBS can often reduce symptoms and sometimes allow lower levodopa doses or change medication response. Adults 21 to 89 with idiopathic Parkinson's who already have GP or STN DBS and existing 7T imaging are eligible, while people with major musculoskeletal or other neurologic disorders, dementia, or post-operative complications are excluded.
- Who can participate?
- Participants must be between 21 Years and 89 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 10 years and 4 months.