Improve cognition through supervised exercise
- Trial ID
- NCT05720468
- Official Title
- Exercise for Cognitive Excellence in Parkinson's Disease
- Goal
- Improve cognition through supervised exercise
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University of California, San Francisco
- Study Type
- INTERVENTIONAL
- Enrollment
- 32 participants
- Conditions
- Parkinson Disease
- Interventions
- Exercise, No Exercise
Summary For Families
The goal is to find out whether a structured, virtually supervised exercise program can preserve or improve thinking and memory in people with Parkinson's. The approach uses regular moderate intensity workouts delivered online to raise heart rate, boost brain blood flow and neurotrophic support, and track changes in cerebrospinal fluid biomarkers via lumbar puncture, with results compared to a no-exercise group. Participants are asked to keep Parkinson's medications stable so the effects of exercise are tested on top of usual treatment. The trial is enrolling people age 40 to 80 with idiopathic Parkinson's and Hoehn and Yahr stage under 4 who can safely exercise and have MoCA scores of 23 or higher; people with uncontrolled medical problems, significant depression, high fall risk, heavy regular exercisers, or lack of access to the virtual program are excluded.
Locations
- University of California San Francisco, San Francisco, California, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Exercise. The goal is to find out whether a structured, virtually supervised exercise program can preserve or improve thinking and memory in people with Parkinson's. The approach uses regular moderate intensity workouts delivered online to raise heart rate, boost brain blood flow and neurotrophic support, and track changes in cerebrospinal fluid biomarkers via lumbar puncture, with results compared to a no-exercise group. Participants are asked to keep Parkinson's medications stable so the effects of exercise are tested on top of usual treatment. The trial is enrolling people age 40 to 80 with idiopathic Parkinson's and Hoehn and Yahr stage under 4 who can safely exercise and have MoCA scores of 23 or higher; people with uncontrolled medical problems, significant depression, high fall risk, heavy regular exercisers, or lack of access to the virtual program are excluded.
- Who can participate?
- Participants must be between 40 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 3 years and 4 months.
- Will I get the real drug or a placebo?
- It depends on the trial design. Some Parkinson's trials are placebo controlled, meaning a portion of participants get an inactive comparison while others get the experimental treatment. Some use crossover designs so everyone eventually receives the active treatment at some point. Observational trials do not use a placebo at all because they are not testing a new treatment. The consent form for any specific trial spells out the design and your odds of being assigned to placebo before you enroll.
- How often will I need to visit the study site?
- Visit frequency varies by trial. Many Parkinson's studies require an in person visit every 4 to 12 weeks during the active treatment phase, with shorter or longer gaps depending on the design. The site coordinator can give you the full visit schedule before you sign anything, so you know what the time commitment looks like.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Will travel or parking be reimbursed?
- Many trials reimburse for parking, mileage, and sometimes lodging if the site is far from your home. Reimbursement policies vary by sponsor and site. When you contact the trial team, ask specifically what is covered and how reimbursement is processed.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.