Exercise for Parkinson's (NCT05720468)
Improve cognition through supervised exercise
- Trial ID
- NCT05720468
- Official Title
- Exercise for Cognitive Excellence in Parkinson's Disease
- Goal
- Improve cognition through supervised exercise
- Phase
- NA
- Status
- COMPLETED
- Sponsor
- University of California, San Francisco
- Study Type
- INTERVENTIONAL
- Enrollment
- 32 participants
- Conditions
- Parkinson Disease
- Interventions
- Exercise, No Exercise
Summary For Families
The goal is to find out whether a structured, virtually supervised exercise program can preserve or improve thinking and memory in people with Parkinson's. The approach uses regular moderate intensity workouts delivered online to raise heart rate, boost brain blood flow and neurotrophic support, and track changes in cerebrospinal fluid biomarkers via lumbar puncture, with results compared to a no-exercise group. Participants are asked to keep Parkinson's medications stable so the effects of exercise are tested on top of usual treatment. The trial is enrolling people age 40 to 80 with idiopathic Parkinson's and Hoehn and Yahr stage under 4 who can safely exercise and have MoCA scores of 23 or higher; people with uncontrolled medical problems, significant depression, high fall risk, heavy regular exercisers, or lack of access to the virtual program are excluded.
Locations
- University of California San Francisco, San Francisco, California, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Exercise. The goal is to find out whether a structured, virtually supervised exercise program can preserve or improve thinking and memory in people with Parkinson's. The approach uses regular moderate intensity workouts delivered online to raise heart rate, boost brain blood flow and neurotrophic support, and track changes in cerebrospinal fluid biomarkers via lumbar puncture, with results compared to a no-exercise group. Participants are asked to keep Parkinson's medications stable so the effects of exercise are tested on top of usual treatment. The trial is enrolling people age 40 to 80 with idiopathic Parkinson's and Hoehn and Yahr stage under 4 who can safely exercise and have MoCA scores of 23 or higher; people with uncontrolled medical problems, significant depression, high fall risk, heavy regular exercisers, or lack of access to the virtual program are excluded.
- Who can participate?
- Participants must be between 40 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 2 years and 10 months.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- This trial has 2 groups, and 1 is a placebo group. Because assignment is random, you have about a 1 in 2 chance (roughly 50%) of being in the placebo group, assuming the groups are filled equally. Ask the coordinator to confirm the exact assignment ratio.
- How many visits does this trial involve?
- Cognitive assessments and patient reported outcomes will be obtained at baseline and at end of 26 weeks.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: Lumbar puncture (spinal tap) (invasive); Thinking & memory tests (non-invasive). Confirm the full schedule with the study coordinator.