Neural Activity Recording for Parkinson's (NCT05820074)
Improve gait using Percept neurostimulation
- Trial ID
- NCT05820074
- Official Title
- Investigating Neural Biomarkers for Gait in Parkinson's Patients
- Goal
- Improve gait using Percept neurostimulation
- Status
- RECRUITING
- Sponsor
- Swiss Federal Institute of Technology
- Study Type
- OBSERVATIONAL
- Enrollment
- 60 participants
- Conditions
- Parkinson Disease, Gait Disorders, Neurologic
- Interventions
- Neural Activity Recording, Movement Parameter Recording, Neuromodulation
Summary For Families
They're looking for specific brain signal patterns tied to walking and balance problems in Parkinson's, so future brain stimulation can be timed or targeted better to reduce freezing, falls, and shuffling. The team records brain rhythms from the implanted Percept PC neurostimulator while tracking movement during walking, comparing data with stimulation turned off to identify electrical signatures that could guide how deep brain stimulation is adjusted alongside medications like levodopa. Adults 18 and up with non-tremor dominant idiopathic PD who have postural instability and gait disturbance, who already have a Percept PC and can tolerate being off stimulation, plus healthy controls without neurological or sensory issues, are being enrolled; people with MoCA under 20 or other interfering conditions are excluded.
Locations
- Cereneo, Vitznau, Canton of Lucerne, Switzerland
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Neural Activity Recording. They're looking for specific brain signal patterns tied to walking and balance problems in Parkinson's, so future brain stimulation can be timed or targeted better to reduce freezing, falls, and shuffling. The team records brain rhythms from the implanted Percept PC neurostimulator while tracking movement during walking, comparing data with stimulation turned off to identify electrical signatures that could guide how deep brain stimulation is adjusted alongside medications like levodopa. Adults 18 and up with non-tremor dominant idiopathic PD who have postural instability and gait disturbance, who already have a Percept PC and can tolerate being off stimulation, plus healthy controls without neurological or sensory issues, are being enrolled; people with MoCA under 20 or other interfering conditions are excluded.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 11 months.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- This is an observational study, so there is no placebo and no experimental treatment is assigned. Researchers observe and collect information while you continue your usual care.
- How many visits does this trial involve?
- One in-person session lasting approximately 2.5 hours.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: Brain surgery / implanted device (invasive); Brain wave recording (EEG) (non-invasive). Confirm the full schedule with the study coordinator.