Optimize brain stimulation improving walking
- Trial ID
- NCT05934747
- Official Title
- Aim 3 Particle Swarm Optimization Postural Instability Gait Disorder
- Goal
- Optimize brain stimulation improving walking
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University of Minnesota
- Study Type
- INTERVENTIONAL
- Enrollment
- 30 participants
- Conditions
- Parkinson's Disease and Parkinsonism
- Interventions
- DBS
Plain-Language Summary
The goal is to reduce postural instability and walking problems in Parkinson's, focusing on balance and gait issues that often do not fully respond to medication. The approach uses your existing deep brain stimulation, DBS, leads in the subthalamic nucleus or globus pallidus and a particle swarm optimization computer method that quickly tests and recommends stimulation settings that better modulate the brain circuits controlling gait and posture. Because the trial tweaks electrical stimulation rather than changing drugs, it can be used alongside levodopa; DBS delivers pulses that alter abnormal brain activity to improve movement, and the algorithm aims to find the pulse patterns most helpful for walking and balance. They are enrolling people 18 to 85 with Parkinson's who already have bilateral STN or GP DBS implanted at least three months, can walk off medication and off stimulation for testing, and meet cognitive screening; candidates must also have preoperative 7T MRI and postoperative CT, and people with other causes of gait impairment, broken DBS contacts, near-depleted IPG batteries, or pregnancy/nursing are excluded.
Locations
- University of Minnesota, Minneapolis, Minnesota, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying DBS. The goal is to reduce postural instability and walking problems in Parkinson's, focusing on balance and gait issues that often do not fully respond to medication. The approach uses your existing deep brain stimulation, DBS, leads in the subthalamic nucleus or globus pallidus and a particle swarm optimization computer method that quickly tests and recommends stimulation settings that better modulate the brain circuits controlling gait and posture. Because the trial tweaks electrical stimulation rather than changing drugs, it can be used alongside levodopa; DBS delivers pulses that alter abnormal brain activity to improve movement, and the algorithm aims to find the pulse patterns most helpful for walking and balance. They are enrolling people 18 to 85 with Parkinson's who already have bilateral STN or GP DBS implanted at least three months, can walk off medication and off stimulation for testing, and meet cognitive screening; candidates must also have preoperative 7T MRI and postoperative CT, and people with other causes of gait impairment, broken DBS contacts, near-depleted IPG batteries, or pregnancy/nursing are excluded.
- Who can participate?
- Participants must be between 18 Years and 85 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 2 years and 3 months.