Understand brain control of breathing
- Trial ID
- NCT06074614
- Official Title
- Neural Control of Breathing in Parkinson's Disease: an Exploratory Study
- Goal
- Understand brain control of breathing
- Status
- RECRUITING
- Sponsor
- Radboud University Medical Center
- Study Type
- OBSERVATIONAL
- Enrollment
- 30 participants
- Conditions
- Parkinson Disease
- Interventions
- Hypercapnic ventilatory response, Respiratory related evoked potential, Transcranial magnetic stimulation
Plain-Language Summary
The goal is to learn how Parkinson's affects the brain's control of breathing, which can help explain symptoms like a blunted response to rising carbon dioxide, cough or swallow problems, and breathlessness. The team will raise CO2 briefly to measure ventilatory drive, record electrical brain responses to breathing loads with respiratory related evoked potentials, and use noninvasive transcranial magnetic stimulation to activate motor brain areas and test how well respiratory pathways respond. Adults 18 and older are eligible, including people with Parkinson's at Hoehn and Yahr stages 1 to 3 and healthy volunteers, while people with other CNS diseases, major lung disease, implanted electronic or certain metal head devices, pregnancy, smoking, epilepsy or prior brain surgery are excluded.
Locations
- Radboudumc, Nijmegen, Gelderland, Netherlands
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Hypercapnic ventilatory response. The goal is to learn how Parkinson's affects the brain's control of breathing, which can help explain symptoms like a blunted response to rising carbon dioxide, cough or swallow problems, and breathlessness. The team will raise CO2 briefly to measure ventilatory drive, record electrical brain responses to breathing loads with respiratory related evoked potentials, and use noninvasive transcranial magnetic stimulation to activate motor brain areas and test how well respiratory pathways respond. Adults 18 and older are eligible, including people with Parkinson's at Hoehn and Yahr stages 1 to 3 and healthy volunteers, while people with other CNS diseases, major lung disease, implanted electronic or certain metal head devices, pregnancy, smoking, epilepsy or prior brain surgery are excluded.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 6 months.