HV-PDAE: High Volume Partnered Dan… for Parkinson's (NCT06088355)
Improve walking speed with exercise
- Trial ID
- NCT06088355
- Official Title
- Moderate Versus High Volume Light-Moderate Intensity Exercise for People With Moderate Parkinson's Disease
- Goal
- Improve walking speed with exercise
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- VA Office of Research and Development
- Study Type
- INTERVENTIONAL
- Enrollment
- 123 participants
- Conditions
- Parkinson Disease, Movement Disorders, Neurodegeneration
- Interventions
- HV-PDAE: High Volume Partnered Dance Aerobic Exercise, MV-PDAE: Moderate Volume Partnered Dance Aerobic Exercise, MV-WALK: Moderate Volume Walking
Summary For Families
Investigators are testing whether packing aerobic exercise into short high-volume weeks, rather than spreading moderate exercise evenly through the month, helps Veterans with mid-stage Parkinson's walk faster, be more active, and show changes in blood markers and blood vessel health. The program uses partnered dance aerobic classes or walking, with the high-volume dance group doing 90-minute classes five days a week for three weeks at the start and then one high-volume week every four weeks, while the moderate groups do 65-minute classes twice a week, all totaling about 112.5 hours over 52 weeks. The main measures are preferred walking cadence recorded with body sensors and overall physical activity, and the team will also look at blood proteins linked to inflammation and nerve support (IL-7, BDNF, and CRP), plus vascular function and fitness. Eligible participants are Veterans age 40 or older with moderate Parkinson's (stages 2 to 3), able to walk at least 10 feet, scoring above 17 on the Montreal Cognitive Assessment, and who show clear benefit from Parkinson's medications; people with severe heart disease, untreated major depression, recent stroke, heavy alcohol use, or certain medication restrictions are excluded.
Locations
- Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying HV-PDAE: High Volume Partnered Dance Aerobic Exercise. Investigators are testing whether packing aerobic exercise into short high-volume weeks, rather than spreading moderate exercise evenly through the month, helps Veterans with mid-stage Parkinson's walk faster, be more active, and show changes in blood markers and blood vessel health. The program uses partnered dance aerobic classes or walking, with the high-volume dance group doing 90-minute classes five days a week for three weeks at the start and then one high-volume week every four weeks, while the moderate groups do 65-minute classes twice a week, all totaling about 112.5 hours over 52 weeks. The main measures are preferred walking cadence recorded with body sensors and overall physical activity, and the team will also look at blood proteins linked to inflammation and nerve support (IL-7, BDNF, and CRP), plus vascular function and fitness. Eligible participants are Veterans age 40 or older with moderate Parkinson's (stages 2 to 3), able to walk at least 10 feet, scoring above 17 on the Montreal Cognitive Assessment, and who show clear benefit from Parkinson's medications; people with severe heart disease, untreated major depression, recent stroke, heavy alcohol use, or certain medication restrictions are excluded.
- Who can participate?
- Participants must be at least 40 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 3 years.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- There is no placebo group. Everyone receives an active treatment; the study compares one treatment against another.
- How many visits does this trial involve?
- Participants attend supervised exercise across 52 weeks: MV-PDAE and MV-WALK classes meet twice-weekly for 65-minutes; HV-PDAE classes meet 5 times a week for 90 minutes for three weeks at trial onset followed by one HV week every 4 weeks for a year.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: Questionnaires & surveys (non-invasive). Confirm the full schedule with the study coordinator.