Deep Brain Stimulation(DBS) and Tr… for Parkinson's (NCT06090682)
Brain stimulation improves thinking skills
- Trial ID
- NCT06090682
- Official Title
- Effect and Mechanism of Deep Brain Stimulation and Transcranial Magnetic Stimulation on Parkinson's Disease With Cognitive Impairment
- Goal
- Brain stimulation improves thinking skills
- Status
- RECRUITING
- Sponsor
- Tianjin Huanhu Hospital
- Study Type
- OBSERVATIONAL
- Enrollment
- 200 participants
- Conditions
- Parkinson Disease, Cognitive Impairment
- Interventions
- Deep Brain Stimulation(DBS) and Transcranial Magnetic Stimulation(TMS)
Summary For Families
The team is looking at how two brain stimulation treatments, deep brain stimulation and transcranial magnetic stimulation, change brain networks and how those changes relate to thinking and memory problems in Parkinson's. They will use advanced brain scans and image analysis to compare structural and functional network changes before and after treatment, link those changes to clinical symptoms, and try to identify the best brain targets for each person to improve thinking. The study plans to enroll about 200 people up to age 75 who have had Parkinson's more than five years, who show at least a 30% motor improvement with levodopa and are candidates for deep brain stimulation surgery; people with severe cognitive or psychiatric problems, atypical Parkinson's, or reasons they cannot have surgery are not eligible.
Locations
- Tianjin Huanhu Hospital, Tianjin, Tianjin Municipality, China
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Deep Brain Stimulation(DBS) and Transcranial Magnetic Stimulation(TMS). The team is looking at how two brain stimulation treatments, deep brain stimulation and transcranial magnetic stimulation, change brain networks and how those changes relate to thinking and memory problems in Parkinson's. They will use advanced brain scans and image analysis to compare structural and functional network changes before and after treatment, link those changes to clinical symptoms, and try to identify the best brain targets for each person to improve thinking. The study plans to enroll about 200 people up to age 75 who have had Parkinson's more than five years, who show at least a 30% motor improvement with levodopa and are candidates for deep brain stimulation surgery; people with severe cognitive or psychiatric problems, atypical Parkinson's, or reasons they cannot have surgery are not eligible.
- Who can participate?
- Participants must be 75 Years or younger.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 3 years.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- This is an observational study, so there is no placebo and no experimental treatment is assigned. Researchers observe and collect information while you continue your usual care.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: Brain surgery / implanted device (invasive); Surgical procedure (invasive); MRI scan (non-invasive). Confirm the full schedule with the study coordinator.