Improve balance using exercise priming
- Trial ID
- NCT06133283
- Official Title
- High Intensity Endurance Exercise as a Primer to Virtual Reality for Optimizing Cortical Excitability and Neuroplasticity in Parkinson's Disease (PD)
- Goal
- Improve balance using exercise priming
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- The University of Texas Health Science Center at San Antonio
- Study Type
- INTERVENTIONAL
- Enrollment
- 16 participants
- Conditions
- Parkinson Disease
- Interventions
- High intensity endurance exercise, Stretching exercise, Virtual reality (VR)-based gaming
Plain-Language Summary
The goal is to test whether a short bout of high intensity endurance exercise done before virtual reality balance games can boost cortical excitability and neuroplasticity, so people with Parkinson's get more benefit for balance and motor learning. The approach compares high intensity aerobic exercise to a stretching control, then has participants do VR-based gaming that practices balance; the idea is that aerobic exercise can raise factors like BDNF and temporarily increase corticomotor excitability, making the brain more ready to learn from the VR practice. The VR sessions give focused, engaging motor practice for balance and gait. The study is looking for people aged 18 to 85 with idiopathic PD in Hoehn and Yahr stages 2 to 3, who have MMSE scores of 23 or higher and a miniBESTest of 21.5 or lower, and who do not have other major neurological, cardiopulmonary, seizure, pregnancy, DBS, or skull/head issues or take medications that alter brain excitability.
Locations
- UT Health San Antonio- Dept. of Physical Therapy, San Antonio, Texas, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying High intensity endurance exercise. The goal is to test whether a short bout of high intensity endurance exercise done before virtual reality balance games can boost cortical excitability and neuroplasticity, so people with Parkinson's get more benefit for balance and motor learning. The approach compares high intensity aerobic exercise to a stretching control, then has participants do VR-based gaming that practices balance; the idea is that aerobic exercise can raise factors like BDNF and temporarily increase corticomotor excitability, making the brain more ready to learn from the VR practice. The VR sessions give focused, engaging motor practice for balance and gait. The study is looking for people aged 18 to 85 with idiopathic PD in Hoehn and Yahr stages 2 to 3, who have MMSE scores of 23 or higher and a miniBESTest of 21.5 or lower, and who do not have other major neurological, cardiopulmonary, seizure, pregnancy, DBS, or skull/head issues or take medications that alter brain excitability.
- Who can participate?
- Participants must be between 18 Years and 85 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 2 years and 11 months.