Slow Parkinson progression through exercise
- Trial ID
- NCT06193252
- Official Title
- Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands
- Goal
- Slow Parkinson progression through exercise
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Radboud University Medical Center
- Study Type
- INTERVENTIONAL
- Enrollment
- 110 participants
- Conditions
- Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Parkinsonian Disorders, REM Sleep Behavior Disorder, Basal Ganglia Diseases, Central Nervous System Diseases, Synucleinopathies, Nervous System Diseases, Cerebral Disorder, Brain Diseases
- Interventions
- Increase of physical activity volume and intensity with the use of a motivational smartphone application
Plain-Language Summary
The goal is to slow or delay the shift from idiopathic REM sleep behavior disorder into Parkinson's disease and related synucleinopathies by boosting early brain resilience. The approach is a non-drug exercise program delivered through a motivational smartphone app with Fitbit monitoring that gradually increases the volume and intensity of physical activity, the idea being that more and stronger aerobic and movement training can improve blood flow, lower inflammation, and support neural circuits that help preserve motor and cognitive function, and because it is a lifestyle intervention it does not involve medications or interact with levodopa. They are enrolling Dutch-speaking adults aged 50 and older who have iRBD, can walk independently, are not already in a high activity range, own a compatible smartphone, live in the community, and do not have a diagnosed neurodegenerative disease, frequent weekly falls, or problems using a phone.
Locations
- Radboud University Medical Center, Nijmegen, Gelderland, Netherlands
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Increase of physical activity volume and intensity with the use of a motivational smartphone application. The goal is to slow or delay the shift from idiopathic REM sleep behavior disorder into Parkinson's disease and related synucleinopathies by boosting early brain resilience. The approach is a non-drug exercise program delivered through a motivational smartphone app with Fitbit monitoring that gradually increases the volume and intensity of physical activity, the idea being that more and stronger aerobic and movement training can improve blood flow, lower inflammation, and support neural circuits that help preserve motor and cognitive function, and because it is a lifestyle intervention it does not involve medications or interact with levodopa. They are enrolling Dutch-speaking adults aged 50 and older who have iRBD, can walk independently, are not already in a high activity range, own a compatible smartphone, live in the community, and do not have a diagnosed neurodegenerative disease, frequent weekly falls, or problems using a phone.
- Who can participate?
- Participants must be at least 50 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 3 years and 11 months.