High-frequency (10Hz) rTMS for Parkinson's (NCT06399731)
Brain stimulation helps thinking problems
- Trial ID
- NCT06399731
- Official Title
- NEuroStimulation for the Treatment of Mild Cognitive Impairment in Parkinson's Disease: an Acceptability Cross-over Study
- Goal
- Brain stimulation helps thinking problems
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Amsterdam UMC
- Study Type
- INTERVENTIONAL
- Enrollment
- 20 participants
- Conditions
- Parkinson Disease, Mild Cognitive Impairment
- Interventions
- High-frequency (10Hz) rTMS, Anodal tDCS
Summary For Families
The goal is to learn whether two types of non-invasive brain stimulation are acceptable and potentially helpful for the mild thinking problems that many people with Parkinson's disease develop. One method is repetitive transcranial magnetic stimulation given in a clinic three times a week for four weeks, and the other is transcranial direct current stimulation done at home five times a week for four weeks, both aimed at the left front part of the brain (the dorsolateral prefrontal cortex); the study will mainly measure acceptability and also look at thinking, mood, and movement, using MRI to help personalize where to target. The team will enroll twenty people with Parkinson's who have mild cognitive impairment (for example a Montreal Cognitive Assessment score of 21 to 25 or lower performance on standard thinking tests), with mild to moderate Parkinson's and stable medication.
Locations
- Amsterdam UMC, Amsterdam, North Holland, Netherlands
Frequently Asked Questions
- What is this trial testing?
- This trial is studying High-frequency (10Hz) rTMS. The goal is to learn whether two types of non-invasive brain stimulation are acceptable and potentially helpful for the mild thinking problems that many people with Parkinson's disease develop. One method is repetitive transcranial magnetic stimulation given in a clinic three times a week for four weeks, and the other is transcranial direct current stimulation done at home five times a week for four weeks, both aimed at the left front part of the brain (the dorsolateral prefrontal cortex); the study will mainly measure acceptability and also look at thinking, mood, and movement, using MRI to help personalize where to target. The team will enroll twenty people with Parkinson's who have mild cognitive impairment (for example a Montreal Cognitive Assessment score of 21 to 25 or lower performance on standard thinking tests), with mild to moderate Parkinson's and stable medication.
- Who can participate?
- Eligibility criteria vary. Check the full listing on ClinicalTrials.gov for detailed inclusion and exclusion criteria.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 6 months.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- This is a crossover trial: instead of staying in one group, you move through a sequence of assignments, so you receive the active treatment during at least one period of the study. Ask the coordinator for the exact sequence and how long each phase lasts.
- How many visits does this trial involve?
- The study has four consecutive phases each lasting 4 weeks.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: MRI scan (non-invasive); Walking & movement tests (non-invasive); Thinking & memory tests (non-invasive). Confirm the full schedule with the study coordinator.