Assess taste function in Parkinsons
- Trial ID
- NCT06439355
- Official Title
- Single-center Study of Gustation in Idiopathic Parkinson's Disease and Lewy Body Disease Using Gustatory Evoked Potential Analysis
- Goal
- Assess taste function in Parkinsons
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Centre Hospitalier Universitaire Dijon
- Study Type
- INTERVENTIONAL
- Enrollment
- 66 participants
- Conditions
- Idiopathic Parkinson's Disease and Lewy Body Disease
- Interventions
- Fasting blood test, Subject interview, Motor assessment, Neurocognitive assessment, Nutritional assessment, Taste tests
Summary For Families
The team is investigating how taste perception and the brain's electrical responses to taste are altered in people with idiopathic Parkinson's disease and Lewy body disease, to help explain common changes in appetite, weight and taste. Participants do taste tests while clinicians record gustatory evoked potentials, which are the electrical signals the nervous system makes in response to taste, plus fasting blood work and motor, cognitive and nutritional assessments to connect taste signal changes with disease features. Adults 18 and older can join, including people with diagnosed IPD or probable/possible LBD and healthy volunteers, and everyone must fast over 2 hours and have BMI under 30; excluded are folks with diabetes, pacemakers, heavy smoking (>4 cigarettes/day), pregnancy, very low cognitive scores (MMSE <15 or MoCA <10), or medications that affect taste. The single-center study in Dijon aims to enroll about 66 participants.
Locations
- Chu Dijon Bourgogne, Dijon, France
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Fasting blood test. The team is investigating how taste perception and the brain's electrical responses to taste are altered in people with idiopathic Parkinson's disease and Lewy body disease, to help explain common changes in appetite, weight and taste. Participants do taste tests while clinicians record gustatory evoked potentials, which are the electrical signals the nervous system makes in response to taste, plus fasting blood work and motor, cognitive and nutritional assessments to connect taste signal changes with disease features. Adults 18 and older can join, including people with diagnosed IPD or probable/possible LBD and healthy volunteers, and everyone must fast over 2 hours and have BMI under 30; excluded are folks with diabetes, pacemakers, heavy smoking (>4 cigarettes/day), pregnancy, very low cognitive scores (MMSE <15 or MoCA <10), or medications that affect taste. The single-center study in Dijon aims to enroll about 66 participants.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 11 months.
- Will I get the real drug or a placebo?
- It depends on the trial design. Some Parkinson's trials are placebo controlled, meaning a portion of participants get an inactive comparison while others get the experimental treatment. Some use crossover designs so everyone eventually receives the active treatment at some point. Observational trials do not use a placebo at all because they are not testing a new treatment. The consent form for any specific trial spells out the design and your odds of being assigned to placebo before you enroll.
- How often will I need to visit the study site?
- Visit frequency varies by trial. Many Parkinson's studies require an in person visit every 4 to 12 weeks during the active treatment phase, with shorter or longer gaps depending on the design. The site coordinator can give you the full visit schedule before you sign anything, so you know what the time commitment looks like.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Will travel or parking be reimbursed?
- Many trials reimburse for parking, mileage, and sometimes lodging if the site is far from your home. Reimbursement policies vary by sponsor and site. When you contact the trial team, ask specifically what is covered and how reimbursement is processed.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.