Detect Parkinson using breath microbiome
- Trial ID
- NCT06453226
- Official Title
- PArkinson's Non-Invasive Volatile ORganic Compound Analysis and Microbiome Assessment (PANORAMA) Study
- Goal
- Detect Parkinson using breath microbiome
- Status
- RECRUITING
- Sponsor
- Imperial College London
- Study Type
- OBSERVATIONAL
- Enrollment
- 120 participants
- Conditions
- Parkinson Disease
Summary For Families
PANORAMA aims to find noninvasive signals in breath and stool that could help detect or track Parkinson's by spotting volatile organic compounds and gut microbiome patterns linked to the disease. The approach is to collect breath samples to measure volatile organic compounds, which are metabolic byproducts from the body and microbes that can change with illness, and stool samples for microbiome sequencing to see how bacterial communities differ in Parkinson's; no drugs or treatments are given. The study is enrolling adults 18 to 90, both people with confirmed or suspected Parkinson's who are having neurological assessment and healthy volunteers including partners or carers, and participants must be off antibiotics or probiotics for at least four weeks, have no diagnosed dysbiotic conditions, and be able to consent.
Locations
- Charing Cross Hospital, Imperial College London, London, United Kingdom
Frequently Asked Questions
- What is this trial testing?
- This trial is studying an experimental treatment. PANORAMA aims to find noninvasive signals in breath and stool that could help detect or track Parkinson's by spotting volatile organic compounds and gut microbiome patterns linked to the disease. The approach is to collect breath samples to measure volatile organic compounds, which are metabolic byproducts from the body and microbes that can change with illness, and stool samples for microbiome sequencing to see how bacterial communities differ in Parkinson's; no drugs or treatments are given. The study is enrolling adults 18 to 90, both people with confirmed or suspected Parkinson's who are having neurological assessment and healthy volunteers including partners or carers, and participants must be off antibiotics or probiotics for at least four weeks, have no diagnosed dysbiotic conditions, and be able to consent.
- Who can participate?
- Participants must be between 18 Years and 90 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 5 months.
- Will I get the real drug or a placebo?
- It depends on the trial design. Some Parkinson's trials are placebo controlled, meaning a portion of participants get an inactive comparison while others get the experimental treatment. Some use crossover designs so everyone eventually receives the active treatment at some point. Observational trials do not use a placebo at all because they are not testing a new treatment. The consent form for any specific trial spells out the design and your odds of being assigned to placebo before you enroll.
- How often will I need to visit the study site?
- Visit frequency varies by trial. Many Parkinson's studies require an in person visit every 4 to 12 weeks during the active treatment phase, with shorter or longer gaps depending on the design. The site coordinator can give you the full visit schedule before you sign anything, so you know what the time commitment looks like.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Will travel or parking be reimbursed?
- Many trials reimburse for parking, mileage, and sometimes lodging if the site is far from your home. Reimbursement policies vary by sponsor and site. When you contact the trial team, ask specifically what is covered and how reimbursement is processed.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.