Parkinson's Trial NCT06453226
Detect Parkinson using breath microbiome
- Trial ID
- NCT06453226
- Official Title
- PArkinson's Non-Invasive Volatile ORganic Compound Analysis and Microbiome Assessment (PANORAMA) Study
- Goal
- Detect Parkinson using breath microbiome
- Status
- UNKNOWN
- Sponsor
- Imperial College London
- Study Type
- OBSERVATIONAL
- Enrollment
- 120 participants
- Conditions
- Parkinson Disease
Summary For Families
PANORAMA aims to find noninvasive signals in breath and stool that could help detect or track Parkinson's by spotting volatile organic compounds and gut microbiome patterns linked to the disease. The approach is to collect breath samples to measure volatile organic compounds, which are metabolic byproducts from the body and microbes that can change with illness, and stool samples for microbiome sequencing to see how bacterial communities differ in Parkinson's; no drugs or treatments are given. The study is enrolling adults 18 to 90, both people with confirmed or suspected Parkinson's who are having neurological assessment and healthy volunteers including partners or carers, and participants must be off antibiotics or probiotics for at least four weeks, have no diagnosed dysbiotic conditions, and be able to consent.
Locations
- Charing Cross Hospital, Imperial College London, London, United Kingdom
Frequently Asked Questions
- What is this trial testing?
- This trial is studying an experimental treatment. PANORAMA aims to find noninvasive signals in breath and stool that could help detect or track Parkinson's by spotting volatile organic compounds and gut microbiome patterns linked to the disease. The approach is to collect breath samples to measure volatile organic compounds, which are metabolic byproducts from the body and microbes that can change with illness, and stool samples for microbiome sequencing to see how bacterial communities differ in Parkinson's; no drugs or treatments are given. The study is enrolling adults 18 to 90, both people with confirmed or suspected Parkinson's who are having neurological assessment and healthy volunteers including partners or carers, and participants must be off antibiotics or probiotics for at least four weeks, have no diagnosed dysbiotic conditions, and be able to consent.
- Who can participate?
- Participants must be between 18 Years and 90 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 5 months.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- This is an observational study, so there is no placebo and no experimental treatment is assigned. Researchers observe and collect information while you continue your usual care.