Targeted brain stimulation reduces depression
- Trial ID
- NCT06467695
- Official Title
- The Effect of MRI-Guided Transcranial Direct Current Stimulation on Cognitive and Affective Symptoms in Persons With Parkinson's Disease and Controls
- Goal
- Targeted brain stimulation reduces depression
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University of South Alabama
- Study Type
- INTERVENTIONAL
- Enrollment
- 40 participants
- Conditions
- Parkinson Disease, Depressive Symptoms
- Interventions
- BIOPAC Stimsola, BIOPAC Stimsola Sham (zero amps)
Plain-Language Summary
The goal is to find out whether MRI-guided transcranial direct current stimulation can reduce cognitive problems and depressive symptoms in people with Parkinson's, with healthy controls included for comparison. Using the BIOPAC Stimsola, a noninvasive device delivers a very weak, targeted electrical current through the scalp guided by each person’s MRI to gently boost or quiet activity in brain regions involved in mood and thinking, while EEG records brain responses; a sham setting uses zero amps so researchers can separate real effects from placebo. The trial is recruiting adults 19 to 65, with the Parkinson's group needing a physician diagnosis and elevated depression on the Beck Depression Inventory, score 20 or higher, and all participants must be able to travel for EEG and tDCS sessions. People with epilepsy, significant traumatic brain injury, or atypical Parkinson's are excluded, and those with deep brain stimulation may join only if their physician agrees to monitor them.
Locations
- University of South Alabama, Mobile, Alabama, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying BIOPAC Stimsola. The goal is to find out whether MRI-guided transcranial direct current stimulation can reduce cognitive problems and depressive symptoms in people with Parkinson's, with healthy controls included for comparison. Using the BIOPAC Stimsola, a noninvasive device delivers a very weak, targeted electrical current through the scalp guided by each person’s MRI to gently boost or quiet activity in brain regions involved in mood and thinking, while EEG records brain responses; a sham setting uses zero amps so researchers can separate real effects from placebo. The trial is recruiting adults 19 to 65, with the Parkinson's group needing a physician diagnosis and elevated depression on the Beck Depression Inventory, score 20 or higher, and all participants must be able to travel for EEG and tDCS sessions. People with epilepsy, significant traumatic brain injury, or atypical Parkinson's are excluded, and those with deep brain stimulation may join only if their physician agrees to monitor them.
- Who can participate?
- Participants must be between 19 Years and 65 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 2 years and 9 months.