Improve thinking through implanted stimulation
- Trial ID
- NCT06518824
- Official Title
- Theta Deep Brain Stimulation for Cognitive Enhancement in Parkinson's Disease
- Goal
- Improve thinking through implanted stimulation
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University of British Columbia
- Study Type
- INTERVENTIONAL
- Enrollment
- 27 participants
- Conditions
- Parkinson Disease, Cognitive Impairment
- Interventions
- DBS On, DBS Off
Plain-Language Summary
They're testing whether theta-frequency stimulation through existing subthalamic nucleus DBS leads can improve memory and attention problems that some people with Parkinson's experience. The team will briefly switch patients' implanted STN DBS devices between usual settings and theta-frequency pulses to try to boost the brain's natural theta rhythms that support learning and attention, this is an adjustment to the implanted DBS hardware used alongside medications like levodopa, not a replacement for them. Adults 18 to 80 who already have STN DBS implants with pre- and post-op imaging, are at least three months post-op, and can complete cognitive testing are eligible, while those with significant dementia, language barriers to testing, or major DBS complications are excluded.
Locations
- Leslie and Gordan Diamond Health Care Centre, Vancouver, British Columbia, Canada
Frequently Asked Questions
- What is this trial testing?
- This trial is studying DBS On. They're testing whether theta-frequency stimulation through existing subthalamic nucleus DBS leads can improve memory and attention problems that some people with Parkinson's experience. The team will briefly switch patients' implanted STN DBS devices between usual settings and theta-frequency pulses to try to boost the brain's natural theta rhythms that support learning and attention, this is an adjustment to the implanted DBS hardware used alongside medications like levodopa, not a replacement for them. Adults 18 to 80 who already have STN DBS implants with pre- and post-op imaging, are at least three months post-op, and can complete cognitive testing are eligible, while those with significant dementia, language barriers to testing, or major DBS complications are excluded.
- Who can participate?
- Participants must be between 18 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 9 months.