cardiovascular training for Parkinson's (NCT06580977)
Enhance Parkinsons cognition via exercise
- Trial ID
- NCT06580977
- Official Title
- Exploring the Effects of Exercise on Memory and Cognition in Parkinson´s Disease
- Goal
- Enhance Parkinsons cognition via exercise
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Heidelberg University
- Study Type
- INTERVENTIONAL
- Enrollment
- 60 participants
- Conditions
- Parkinson Disease
- Interventions
- cardiovascular training, stretching
Summary For Families
They want to know whether regular aerobic cardiovascular exercise can improve memory and other thinking skills that often decline in Parkinson's. Participants will do a supervised aerobic training program or a stretching program as a low-intensity comparison; the aerobic work raises heart rate to increase blood flow and oxygen delivery and to stimulate brain-supporting factors like BDNF that help learning and memory. Exercise does not directly change how levodopa works, so it is meant to complement existing medications rather than replace them. Looking for people aged 50 to 80 with Parkinson's at Hoehn and Yahr stage 3 or lower who can stand and walk 10 meters, are naive to the memory tests, have only mild or no cognitive impairment (MoCA 21+), no deep brain stimulation, no major psychiatric or other conditions that would interfere, and who are not already doing high levels of cardiovascular exercise.
Locations
- Heidelberg University, Heidelberg, Baden-Wurttemberg, Germany
Frequently Asked Questions
- What is this trial testing?
- This trial is studying cardiovascular training. They want to know whether regular aerobic cardiovascular exercise can improve memory and other thinking skills that often decline in Parkinson's. Participants will do a supervised aerobic training program or a stretching program as a low-intensity comparison; the aerobic work raises heart rate to increase blood flow and oxygen delivery and to stimulate brain-supporting factors like BDNF that help learning and memory. Exercise does not directly change how levodopa works, so it is meant to complement existing medications rather than replace them. Looking for people aged 50 to 80 with Parkinson's at Hoehn and Yahr stage 3 or lower who can stand and walk 10 meters, are naive to the memory tests, have only mild or no cognitive impairment (MoCA 21+), no deep brain stimulation, no major psychiatric or other conditions that would interfere, and who are not already doing high levels of cardiovascular exercise.
- Who can participate?
- Participants must be between 50 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 2 years and 9 months.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- There is no placebo group. Everyone receives an active treatment; the study compares one treatment against another.
- How many visits does this trial involve?
- 36 training sessions over twelve weeks (three times per week), each session 30 to 55 min.