Neurofeedback for Parkinson's (NCT06582355)
Reduce motor symptoms using neurofeedback
- Trial ID
- NCT06582355
- Official Title
- MOTOR-NF - a Randomized Controlled Trial of FMRI-based Neurofeedback for Motor Symptoms of Parkinson's Disease
- Goal
- Reduce motor symptoms using neurofeedback
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Maastricht University Medical Center
- Study Type
- INTERVENTIONAL
- Enrollment
- 60 participants
- Conditions
- Parkinson Disease
- Interventions
- Neurofeedback, Kinesthetic imagery
Summary For Families
It aims to help people with Parkinson's improve motor symptoms like slowness and stiffness by training the brain's motor networks. Using real-time fMRI neurofeedback plus kinesthetic imagery, participants watch live feedback of activity in their motor cortex and use imagined, felt movements to learn to increase or normalize that activity, a noninvasive brain-training approach that can be used alongside usual medications such as levodopa. They are enrolling adults 18 and older with Parkinson's in Hoehn and Yahr stages 1 to 3 who can safely have an MRI, score at least 24 on the MoCA, and have no history of psychotic or bipolar disorders, recent illegal drug use, or MRI-incompatible implants. About 60 people will be enrolled at Maastricht University Medical Center.
Locations
- Uniklinik Köln, Cologne, Germany
- Maastricht University, Maastricht, Netherlands
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Neurofeedback. It aims to help people with Parkinson's improve motor symptoms like slowness and stiffness by training the brain's motor networks. Using real-time fMRI neurofeedback plus kinesthetic imagery, participants watch live feedback of activity in their motor cortex and use imagined, felt movements to learn to increase or normalize that activity, a noninvasive brain-training approach that can be used alongside usual medications such as levodopa. They are enrolling adults 18 and older with Parkinson's in Hoehn and Yahr stages 1 to 3 who can safely have an MRI, score at least 24 on the MoCA, and have no history of psychotic or bipolar disorders, recent illegal drug use, or MRI-incompatible implants. About 60 people will be enrolled at Maastricht University Medical Center.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 2 locations.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 5 months.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- There is no placebo group. Everyone receives an active treatment; the study compares one treatment against another.
- How many visits does this trial involve?
- You will have 4 in-person MRI sessions spread over approximately one month.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: Brain surgery / implanted device (invasive); MRI scan (non-invasive). Confirm the full schedule with the study coordinator.