Detect freezing through oculomotor markers
- Trial ID
- NCT06663826
- Official Title
- Development of Digital Diagnostic Devices for Parkinson's Disease
- Goal
- Detect freezing through oculomotor markers
- Status
- RECRUITING
- Sponsor
- machineMD AG
- Study Type
- OBSERVATIONAL
- Enrollment
- 100 participants
- Conditions
- Parkinson Disease
- Interventions
- oculomotor and pupillary function assessment
Summary For Families
They want to see whether digital measurements of eye movements and pupil reactions can reveal brain changes linked to walking problems in Parkinson's, especially daily freezing or festination. The study uses oculomotor and pupillary assessments recorded by digital devices, potentially at home over WiFi, to capture objective markers of balance and gait while allowing regular Parkinson's medications but excluding drugs that blunt eye responses. Looking for people with Parkinson's or atypical parkinsonism who can report daily freezing or festination, have a refractive error between -6 and +4 diopters, can walk unsupported or with an aid for at least five minutes, and who do not have other neurological diseases, eye or skin issues that affect measurements, interfering medications, severe cognitive problems, or poor home WiFi.
Locations
- University Hospital of Zurich, Zurich, Canton of Zurich, Switzerland
Frequently Asked Questions
- What is this trial testing?
- This trial is studying oculomotor and pupillary function assessment. They want to see whether digital measurements of eye movements and pupil reactions can reveal brain changes linked to walking problems in Parkinson's, especially daily freezing or festination. The study uses oculomotor and pupillary assessments recorded by digital devices, potentially at home over WiFi, to capture objective markers of balance and gait while allowing regular Parkinson's medications but excluding drugs that blunt eye responses. Looking for people with Parkinson's or atypical parkinsonism who can report daily freezing or festination, have a refractive error between -6 and +4 diopters, can walk unsupported or with an aid for at least five minutes, and who do not have other neurological diseases, eye or skin issues that affect measurements, interfering medications, severe cognitive problems, or poor home WiFi.
- Who can participate?
- Eligibility criteria vary. Check the full listing on ClinicalTrials.gov for detailed inclusion and exclusion criteria.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 9 months.
- Will I get the real drug or a placebo?
- It depends on the trial design. Some Parkinson's trials are placebo controlled, meaning a portion of participants get an inactive comparison while others get the experimental treatment. Some use crossover designs so everyone eventually receives the active treatment at some point. Observational trials do not use a placebo at all because they are not testing a new treatment. The consent form for any specific trial spells out the design and your odds of being assigned to placebo before you enroll.
- How often will I need to visit the study site?
- Visit frequency varies by trial. Many Parkinson's studies require an in person visit every 4 to 12 weeks during the active treatment phase, with shorter or longer gaps depending on the design. The site coordinator can give you the full visit schedule before you sign anything, so you know what the time commitment looks like.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Will travel or parking be reimbursed?
- Many trials reimburse for parking, mileage, and sometimes lodging if the site is far from your home. Reimbursement policies vary by sponsor and site. When you contact the trial team, ask specifically what is covered and how reimbursement is processed.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.