DBS stimulation for Parkinson's (NCT06692920)
Map brain signals causing tremor
- Trial ID
- NCT06692920
- Official Title
- Characterizing the Pathophysiological Role of the Pallido-thalamocortical Motor Pathway in Parkinson's Disease.
- Goal
- Map brain signals causing tremor
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University of Minnesota
- Study Type
- INTERVENTIONAL
- Enrollment
- 25 participants
- Conditions
- Parkinson Disease
- Interventions
- DBS stimulation
Summary For Families
The goal is to map how the pallido-thalamocortical motor pathway contributes to Parkinson's motor problems, so clinicians can better understand the circuit-level causes of tremor, slowness, and stiffness. During the participant's planned deep brain stimulation surgery at the University of Minnesota, researchers will apply and record DBS stimulation to probe how electrical pulses change activity along that pathway; DBS delivers controlled electrical pulses to deep brain targets to normalize or interrupt abnormal firing that drives symptoms. This work is focused on brain circuit signals during routine DBS care rather than testing a new drug. The study is looking for adults aged 21 to 75 with idiopathic Parkinson's who are already scheduled for DBS at UMN, excluding people with other major neurologic disorders, dementia, certain post-op complications, pregnancy, or recent unsafe research radiation exposure.
Locations
- University of Minnesota, Minneapolis, Minnesota, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying DBS stimulation. The goal is to map how the pallido-thalamocortical motor pathway contributes to Parkinson's motor problems, so clinicians can better understand the circuit-level causes of tremor, slowness, and stiffness. During the participant's planned deep brain stimulation surgery at the University of Minnesota, researchers will apply and record DBS stimulation to probe how electrical pulses change activity along that pathway; DBS delivers controlled electrical pulses to deep brain targets to normalize or interrupt abnormal firing that drives symptoms. This work is focused on brain circuit signals during routine DBS care rather than testing a new drug. The study is looking for adults aged 21 to 75 with idiopathic Parkinson's who are already scheduled for DBS at UMN, excluding people with other major neurologic disorders, dementia, certain post-op complications, pregnancy, or recent unsafe research radiation exposure.
- Who can participate?
- Participants must be between 21 Years and 75 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 2 years.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- Everyone in this trial receives the experimental treatment. There is no placebo group.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: Surgical procedure (invasive); Brain surgery / implanted device (invasive). Confirm the full schedule with the study coordinator.