Map brain signals causing tremor
- Trial ID
- NCT06692920
- Official Title
- Characterizing the Pathophysiological Role of the Pallido-thalamocortical Motor Pathway in Parkinson's Disease.
- Goal
- Map brain signals causing tremor
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University of Minnesota
- Study Type
- INTERVENTIONAL
- Enrollment
- 25 participants
- Conditions
- Parkinson Disease
- Interventions
- DBS stimulation
Plain-Language Summary
The goal is to map how the pallido-thalamocortical motor pathway contributes to Parkinson's motor problems, so clinicians can better understand the circuit-level causes of tremor, slowness, and stiffness. During the participant's planned deep brain stimulation surgery at the University of Minnesota, researchers will apply and record DBS stimulation to probe how electrical pulses change activity along that pathway; DBS delivers controlled electrical pulses to deep brain targets to normalize or interrupt abnormal firing that drives symptoms. This work is focused on brain circuit signals during routine DBS care rather than testing a new drug. The study is looking for adults aged 21 to 75 with idiopathic Parkinson's who are already scheduled for DBS at UMN, excluding people with other major neurologic disorders, dementia, certain post-op complications, pregnancy, or recent unsafe research radiation exposure.
Locations
- University of Minnesota, Minneapolis, Minnesota, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying DBS stimulation. The goal is to map how the pallido-thalamocortical motor pathway contributes to Parkinson's motor problems, so clinicians can better understand the circuit-level causes of tremor, slowness, and stiffness. During the participant's planned deep brain stimulation surgery at the University of Minnesota, researchers will apply and record DBS stimulation to probe how electrical pulses change activity along that pathway; DBS delivers controlled electrical pulses to deep brain targets to normalize or interrupt abnormal firing that drives symptoms. This work is focused on brain circuit signals during routine DBS care rather than testing a new drug. The study is looking for adults aged 21 to 75 with idiopathic Parkinson's who are already scheduled for DBS at UMN, excluding people with other major neurologic disorders, dementia, certain post-op complications, pregnancy, or recent unsafe research radiation exposure.
- Who can participate?
- Participants must be between 21 Years and 75 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 2 years.