Steadier brain pulses reduce tremor
- Trial ID
- NCT06742450
- Official Title
- Prospective Study of Constant Current Versus Constant Voltage Deep Brain Stimulation in Patients with Parkinson's Disease
- Goal
- Steadier brain pulses reduce tremor
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Xuanwu Hospital, Beijing
- Study Type
- INTERVENTIONAL
- Enrollment
- 180 participants
- Conditions
- Parkinson's Disease (PD)
- Interventions
- Constant current (CC) subthalamic nucleus deep brain stimulation, Constant voltage (CV) subthalamic nucleus deep brain stimulation
Plain-Language Summary
They're testing whether delivering stimulation as constant current or constant voltage at the subthalamic nucleus gives steadier, more effective control of motor symptoms with fewer side effects. The approach uses bilateral STN-DBS with either constant current, which keeps the electrical current steady despite changes in tissue impedance, or constant voltage, which holds voltage steady so the actual current can vary; DBS sends pulses to normalize abnormal STN activity, improving tremor, stiffness, and slowness, and often lets people reduce or smooth out levodopa dosing. The trial seeks adults 18 to 75 with idiopathic Parkinson's who already have bilateral STN-DBS electrodes implanted but not yet powered on. People with dementia, major medical problems, epilepsy, pregnancy, severely misplaced electrodes, or inability to consent or follow up are excluded.
Locations
- Xuanwu Hospital of Capital Medical University, Beijing, China
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Constant current (CC) subthalamic nucleus deep brain stimulation. They're testing whether delivering stimulation as constant current or constant voltage at the subthalamic nucleus gives steadier, more effective control of motor symptoms with fewer side effects. The approach uses bilateral STN-DBS with either constant current, which keeps the electrical current steady despite changes in tissue impedance, or constant voltage, which holds voltage steady so the actual current can vary; DBS sends pulses to normalize abnormal STN activity, improving tremor, stiffness, and slowness, and often lets people reduce or smooth out levodopa dosing. The trial seeks adults 18 to 75 with idiopathic Parkinson's who already have bilateral STN-DBS electrodes implanted but not yet powered on. People with dementia, major medical problems, epilepsy, pregnancy, severely misplaced electrodes, or inability to consent or follow up are excluded.
- Who can participate?
- Participants must be between 18 Years and 75 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 2 years and 2 months.