Reduce freezing and improve walking
- Trial ID
- NCT06791902
- Official Title
- Study on Preliminary Safety and Efficacy of Adaptive DBS Aligned to Locomotor States to Improve Locomotor Functions in Parkinson's Patients
- Goal
- Reduce freezing and improve walking
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Jocelyne Bloch
- Study Type
- INTERVENTIONAL
- Enrollment
- 10 participants
- Conditions
- Parkinson Disease
- Interventions
- Adaptive DBS
Summary For Families
The goal is to improve gait and balance problems in Parkinson's, for example reducing freezing of gait and making walking steadier. The approach uses adaptive deep brain stimulation with the implanted Medtronic Percept system, which reads local field potentials tied to walking and automatically adjusts stimulation in real time so the brain gets different patterns of stimulation during walking versus standing. It works alongside your current DBS device and Parkinson medications, targeting the specific brain rhythms linked to locomotion rather than delivering constant stimulation. The trial is looking for adults 18 and older who already have a full Medtronic Percept suite with bilateral leads, have gait or balance disorders with detectable LFP markers related to locomotion, can consent in French, and meet the study safety criteria.
Locations
- CHUV, Lausanne, Canton of Vaud, Switzerland
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Adaptive DBS. The goal is to improve gait and balance problems in Parkinson's, for example reducing freezing of gait and making walking steadier. The approach uses adaptive deep brain stimulation with the implanted Medtronic Percept system, which reads local field potentials tied to walking and automatically adjusts stimulation in real time so the brain gets different patterns of stimulation during walking versus standing. It works alongside your current DBS device and Parkinson medications, targeting the specific brain rhythms linked to locomotion rather than delivering constant stimulation. The trial is looking for adults 18 and older who already have a full Medtronic Percept suite with bilateral leads, have gait or balance disorders with detectable LFP markers related to locomotion, can consent in French, and meet the study safety criteria.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 2 years.
- Will I get the real drug or a placebo?
- It depends on the trial design. Some Parkinson's trials are placebo controlled, meaning a portion of participants get an inactive comparison while others get the experimental treatment. Some use crossover designs so everyone eventually receives the active treatment at some point. Observational trials do not use a placebo at all because they are not testing a new treatment. The consent form for any specific trial spells out the design and your odds of being assigned to placebo before you enroll.
- How often will I need to visit the study site?
- Visit frequency varies by trial. Many Parkinson's studies require an in person visit every 4 to 12 weeks during the active treatment phase, with shorter or longer gaps depending on the design. The site coordinator can give you the full visit schedule before you sign anything, so you know what the time commitment looks like.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Will travel or parking be reimbursed?
- Many trials reimburse for parking, mileage, and sometimes lodging if the site is far from your home. Reimbursement policies vary by sponsor and site. When you contact the trial team, ask specifically what is covered and how reimbursement is processed.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.