Adaptive DBS for Parkinson's (NCT06791902)
Reduce freezing and improve walking
- Trial ID
- NCT06791902
- Official Title
- Study on Preliminary Safety and Efficacy of Adaptive DBS Aligned to Locomotor States to Improve Locomotor Functions in Parkinson's Patients
- Goal
- Reduce freezing and improve walking
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Jocelyne Bloch
- Study Type
- INTERVENTIONAL
- Enrollment
- 10 participants
- Conditions
- Parkinson Disease
- Interventions
- Adaptive DBS
Summary For Families
The goal is to improve gait and balance problems in Parkinson's, for example reducing freezing of gait and making walking steadier. The approach uses adaptive deep brain stimulation with the implanted Medtronic Percept system, which reads local field potentials tied to walking and automatically adjusts stimulation in real time so the brain gets different patterns of stimulation during walking versus standing. It works alongside your current DBS device and Parkinson medications, targeting the specific brain rhythms linked to locomotion rather than delivering constant stimulation. The trial is looking for adults 18 and older who already have a full Medtronic Percept suite with bilateral leads, have gait or balance disorders with detectable LFP markers related to locomotion, can consent in French, and meet the study safety criteria.
Locations
- CHUV, Lausanne, Canton of Vaud, Switzerland
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Adaptive DBS. The goal is to improve gait and balance problems in Parkinson's, for example reducing freezing of gait and making walking steadier. The approach uses adaptive deep brain stimulation with the implanted Medtronic Percept system, which reads local field potentials tied to walking and automatically adjusts stimulation in real time so the brain gets different patterns of stimulation during walking versus standing. It works alongside your current DBS device and Parkinson medications, targeting the specific brain rhythms linked to locomotion rather than delivering constant stimulation. The trial is looking for adults 18 and older who already have a full Medtronic Percept suite with bilateral leads, have gait or balance disorders with detectable LFP markers related to locomotion, can consent in French, and meet the study safety criteria.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 2 years.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- Everyone in this trial receives the experimental treatment. There is no placebo group.
- How many visits does this trial involve?
- The study will take place on 3 different days over a maximum of 5 weeks.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: Brain surgery / implanted device (invasive). Confirm the full schedule with the study coordinator.