Improve walking endurance and strength
- Trial ID
- NCT06893055
- Official Title
- Strength-Endurance Circuit Training in Parkinson's Disease: Effects on Disease Severity, Physical Performance, Blood Biomarkers and Quality of Life.
- Goal
- Improve walking endurance and strength
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- General University Hospital, Prague
- Study Type
- INTERVENTIONAL
- Enrollment
- 90 participants
- Conditions
- Parkinson Disease, Idiopathic
- Interventions
- Strength-Endurance Training, Endurance Training
Summary For Families
Researchers want to know whether a structured strength-endurance circuit program can lessen Parkinson's signs, boost physical performance, shift blood biomarkers linked to brain health, and improve quality of life compared with regular endurance training. The program uses supervised circuits that combine resistance exercises to build muscle strength and endurance with aerobic intervals to raise cardiovascular fitness, a combination meant to improve mobility and daily function and that may increase helpful proteins like BDNF and reduce inflammatory markers, while complementing stable levodopa or other dopaminergic medications rather than replacing them. The trial is looking for adults 18 to 75 with idiopathic Parkinson's at Hoehn and Yahr stage up to 2.5 who can walk without support and are on stable dopaminergic treatment; people with deep brain stimulation, freezing of gait, camptocormia, major limiting health issues, or low expected attendance are excluded.
Locations
- Department of Neurology and Centre of Clinical Neuroscience First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Prague, Czechia
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Strength-Endurance Training. Researchers want to know whether a structured strength-endurance circuit program can lessen Parkinson's signs, boost physical performance, shift blood biomarkers linked to brain health, and improve quality of life compared with regular endurance training. The program uses supervised circuits that combine resistance exercises to build muscle strength and endurance with aerobic intervals to raise cardiovascular fitness, a combination meant to improve mobility and daily function and that may increase helpful proteins like BDNF and reduce inflammatory markers, while complementing stable levodopa or other dopaminergic medications rather than replacing them. The trial is looking for adults 18 to 75 with idiopathic Parkinson's at Hoehn and Yahr stage up to 2.5 who can walk without support and are on stable dopaminergic treatment; people with deep brain stimulation, freezing of gait, camptocormia, major limiting health issues, or low expected attendance are excluded.
- Who can participate?
- Participants must be between 18 Years and 75 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 9 months.
- Will I get the real drug or a placebo?
- It depends on the trial design. Some Parkinson's trials are placebo controlled, meaning a portion of participants get an inactive comparison while others get the experimental treatment. Some use crossover designs so everyone eventually receives the active treatment at some point. Observational trials do not use a placebo at all because they are not testing a new treatment. The consent form for any specific trial spells out the design and your odds of being assigned to placebo before you enroll.
- How often will I need to visit the study site?
- Visit frequency varies by trial. Many Parkinson's studies require an in person visit every 4 to 12 weeks during the active treatment phase, with shorter or longer gaps depending on the design. The site coordinator can give you the full visit schedule before you sign anything, so you know what the time commitment looks like.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Will travel or parking be reimbursed?
- Many trials reimburse for parking, mileage, and sometimes lodging if the site is far from your home. Reimbursement policies vary by sponsor and site. When you contact the trial team, ask specifically what is covered and how reimbursement is processed.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.