Improve walking endurance and strength
- Trial ID
- NCT06893055
- Official Title
- Strength-Endurance Circuit Training in Parkinson's Disease: Effects on Disease Severity, Physical Performance, Blood Biomarkers and Quality of Life.
- Goal
- Improve walking endurance and strength
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- General University Hospital, Prague
- Study Type
- INTERVENTIONAL
- Enrollment
- 90 participants
- Conditions
- Parkinson Disease, Idiopathic
- Interventions
- Strength-Endurance Training, Endurance Training
Plain-Language Summary
Researchers want to know whether a structured strength-endurance circuit program can lessen Parkinson's signs, boost physical performance, shift blood biomarkers linked to brain health, and improve quality of life compared with regular endurance training. The program uses supervised circuits that combine resistance exercises to build muscle strength and endurance with aerobic intervals to raise cardiovascular fitness, a combination meant to improve mobility and daily function and that may increase helpful proteins like BDNF and reduce inflammatory markers, while complementing stable levodopa or other dopaminergic medications rather than replacing them. The trial is looking for adults 18 to 75 with idiopathic Parkinson's at Hoehn and Yahr stage up to 2.5 who can walk without support and are on stable dopaminergic treatment; people with deep brain stimulation, freezing of gait, camptocormia, major limiting health issues, or low expected attendance are excluded.
Locations
- Department of Neurology and Centre of Clinical Neuroscience First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Prague, Czechia
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Strength-Endurance Training. Researchers want to know whether a structured strength-endurance circuit program can lessen Parkinson's signs, boost physical performance, shift blood biomarkers linked to brain health, and improve quality of life compared with regular endurance training. The program uses supervised circuits that combine resistance exercises to build muscle strength and endurance with aerobic intervals to raise cardiovascular fitness, a combination meant to improve mobility and daily function and that may increase helpful proteins like BDNF and reduce inflammatory markers, while complementing stable levodopa or other dopaminergic medications rather than replacing them. The trial is looking for adults 18 to 75 with idiopathic Parkinson's at Hoehn and Yahr stage up to 2.5 who can walk without support and are on stable dopaminergic treatment; people with deep brain stimulation, freezing of gait, camptocormia, major limiting health issues, or low expected attendance are excluded.
- Who can participate?
- Participants must be between 18 Years and 75 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 9 months.