Brain stimulation reduces sleep fragmentation
- Trial ID
- NCT06914466
- Official Title
- Neural Mechanisms and Clinical Applications of Deep Brain Stimulation for Modulating Sleep Dysregulation in Parkinson's Disease
- Goal
- Brain stimulation reduces sleep fragmentation
- Status
- RECRUITING
- Sponsor
- Xuanwu Hospital, Beijing
- Study Type
- OBSERVATIONAL
- Enrollment
- 20 participants
- Conditions
- Deep Brain Stimulation, Parkinson's Disease and Parkinsonism, Sleep Disorder
- Interventions
- Deep Brain Stimulation
Plain-Language Summary
The team wants to understand how stimulating the subthalamic nucleus can change the brain circuits that control sleep in Parkinson's, and whether specific stimulation patterns can reduce sleep fragmentation, REM sleep behavior problems, or daytime sleepiness. Using people who already have bilateral STN-DBS with the Medtronic Percept PC, researchers will compare sleep questionnaires, sleep studies, and the device's recorded brain signals to see which stimulation settings link to better sleep, STN-DBS delivers targeted electrical pulses that reshape overactive motor and nonmotor networks while the Percept records local field potentials to reveal neural activity behind sleep changes. They plan to enroll about 20 adults age 19 to 80 who had bilateral STN-DBS with the Percept PC and can complete follow-up, excluding those with other brain surgery, secondary Parkinsonism, other major nervous system diseases, severe medical or psychiatric illness, or major cognitive or communication barriers.
Locations
- Xuanwu Hospital,Capital Medical University, Beijing, Beijing Municipality, China
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Deep Brain Stimulation. The team wants to understand how stimulating the subthalamic nucleus can change the brain circuits that control sleep in Parkinson's, and whether specific stimulation patterns can reduce sleep fragmentation, REM sleep behavior problems, or daytime sleepiness. Using people who already have bilateral STN-DBS with the Medtronic Percept PC, researchers will compare sleep questionnaires, sleep studies, and the device's recorded brain signals to see which stimulation settings link to better sleep, STN-DBS delivers targeted electrical pulses that reshape overactive motor and nonmotor networks while the Percept records local field potentials to reveal neural activity behind sleep changes. They plan to enroll about 20 adults age 19 to 80 who had bilateral STN-DBS with the Percept PC and can complete follow-up, excluding those with other brain surgery, secondary Parkinsonism, other major nervous system diseases, severe medical or psychiatric illness, or major cognitive or communication barriers.
- Who can participate?
- Participants must be between 19 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 2 years.