Predict brain stimulation easing freezing
- Trial ID
- NCT06951906
- Official Title
- Imaging Biomarkers of Freezing of Gait Response to Deep Brain Stimulation
- Goal
- Predict brain stimulation easing freezing
- Phase
- PHASE4
- Status
- RECRUITING
- Sponsor
- Medical University of South Carolina
- Study Type
- INTERVENTIONAL
- Enrollment
- 54 participants
- Conditions
- Freezing of Gait Symptoms in Parkinson's Disease, Deep Brain Stimulation
- Interventions
- fMRI
Plain-Language Summary
The goal is to identify brain imaging markers that predict whether subthalamic nucleus deep brain stimulation will help with freezing of gait in people with Parkinson's. The team uses fMRI to map brain activity linked to freezing and to the response to DBS, while the DBS itself delivers continuous electrical pulses to the subthalamic nucleus to modulate abnormal motor circuits, often improving tremor and motor fluctuations and sometimes allowing lower levodopa doses, though effects on freezing can vary. The study is for adults over 40 with Parkinson's by UK Brain Bank criteria who have documented freezing of gait and have been clinically selected for STN-DBS at MUSC; people with non-PD gait problems, inability to complete OFF-state gait tests, MRI contraindications, or non-3T MRI compatible DBS devices are excluded.
Locations
- Medical University of South Carolina, Charleston, South Carolina, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying fMRI. The goal is to identify brain imaging markers that predict whether subthalamic nucleus deep brain stimulation will help with freezing of gait in people with Parkinson's. The team uses fMRI to map brain activity linked to freezing and to the response to DBS, while the DBS itself delivers continuous electrical pulses to the subthalamic nucleus to modulate abnormal motor circuits, often improving tremor and motor fluctuations and sometimes allowing lower levodopa doses, though effects on freezing can vary. The study is for adults over 40 with Parkinson's by UK Brain Bank criteria who have documented freezing of gait and have been clinically selected for STN-DBS at MUSC; people with non-PD gait problems, inability to complete OFF-state gait tests, MRI contraindications, or non-3T MRI compatible DBS devices are excluded.
- Who can participate?
- Participants must be at least 40 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This Phase 4 trial is estimated to last approximately 5 years.