Parkinson's Trial NCT06977204
Lower brain inflammation using exercise
- Trial ID
- NCT06977204
- Official Title
- Role of Physical Activity on Neuroinflammation in Parkinson's Disease
- Goal
- Lower brain inflammation using exercise
- Status
- RECRUITING
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
- Study Type
- OBSERVATIONAL
- Enrollment
- 40 participants
- Conditions
- Parkinson Disease, Physical Inactivity, Physical Disability
Summary For Families
They want to find out whether higher levels of physical activity can lower neuroinflammation that may drive symptom progression and disability in Parkinson's. The study watches how people move in daily life and relates activity to biological signs of inflammation and protective brain factors, since exercise is thought to reduce pro‑inflammatory cytokines and boost neurotrophic support like BDNF. Looking for adults aged 40 to 80 with Parkinson's at Hoehn and Yahr stages 1 to 3. People with dementia, severe depression, deep brain stimulation implants or Duodopa therapy, BMI 30 or higher, active smokers, recent infections, or taking antioxidants such as N‑acetylcysteine are excluded.
Locations
- IRCCS Mondino Foundation, Pavia, Pavia, Italy
Frequently Asked Questions
- What is this trial testing?
- This trial is studying an experimental treatment. They want to find out whether higher levels of physical activity can lower neuroinflammation that may drive symptom progression and disability in Parkinson's. The study watches how people move in daily life and relates activity to biological signs of inflammation and protective brain factors, since exercise is thought to reduce pro‑inflammatory cytokines and boost neurotrophic support like BDNF. Looking for adults aged 40 to 80 with Parkinson's at Hoehn and Yahr stages 1 to 3. People with dementia, severe depression, deep brain stimulation implants or Duodopa therapy, BMI 30 or higher, active smokers, recent infections, or taking antioxidants such as N‑acetylcysteine are excluded.
- Who can participate?
- Participants must be between 40 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 3 years.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- This is an observational study, so there is no placebo and no experimental treatment is assigned. Researchers observe and collect information while you continue your usual care.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: Blood draw (minimally invasive); Questionnaires & surveys (non-invasive); Walking & movement tests (non-invasive). Confirm the full schedule with the study coordinator.