Lower brain inflammation using exercise
- Trial ID
- NCT06977204
- Official Title
- Role of Physical Activity on Neuroinflammation in Parkinson's Disease
- Goal
- Lower brain inflammation using exercise
- Status
- RECRUITING
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
- Study Type
- OBSERVATIONAL
- Enrollment
- 40 participants
- Conditions
- Parkinson Disease, Physical Inactivity, Physical Disability
Plain-Language Summary
They want to find out whether higher levels of physical activity can lower neuroinflammation that may drive symptom progression and disability in Parkinson's. The study watches how people move in daily life and relates activity to biological signs of inflammation and protective brain factors, since exercise is thought to reduce pro‑inflammatory cytokines and boost neurotrophic support like BDNF. Looking for adults aged 40 to 80 with Parkinson's at Hoehn and Yahr stages 1 to 3. People with dementia, severe depression, deep brain stimulation implants or Duodopa therapy, BMI 30 or higher, active smokers, recent infections, or taking antioxidants such as N‑acetylcysteine are excluded.
Locations
- IRCCS Mondino Foundation, Pavia, Pavia, Italy
Frequently Asked Questions
- What is this trial testing?
- This trial is studying an experimental treatment. They want to find out whether higher levels of physical activity can lower neuroinflammation that may drive symptom progression and disability in Parkinson's. The study watches how people move in daily life and relates activity to biological signs of inflammation and protective brain factors, since exercise is thought to reduce pro‑inflammatory cytokines and boost neurotrophic support like BDNF. Looking for adults aged 40 to 80 with Parkinson's at Hoehn and Yahr stages 1 to 3. People with dementia, severe depression, deep brain stimulation implants or Duodopa therapy, BMI 30 or higher, active smokers, recent infections, or taking antioxidants such as N‑acetylcysteine are excluded.
- Who can participate?
- Participants must be between 40 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 3 years.