TMS+ Gait training for Parkinson's (NCT06982638)
Reduce freezing episodes during walking
- Trial ID
- NCT06982638
- Official Title
- Accelerated TMS for Freezing of Gait in Parkinson's Disease
- Goal
- Reduce freezing episodes during walking
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Medical University of South Carolina
- Study Type
- INTERVENTIONAL
- Enrollment
- 12 participants
- Conditions
- Parkinson's Disease (PD)
- Interventions
- TMS+ Gait training
Summary For Families
The goal is to learn whether a personalized form of repeated magnetic brain stimulation, given with walking practice, is practical and tolerable and shows early signs of helping people with Parkinson's who experience freezing of gait, the sudden feeling of being stuck when trying to walk. The approach uses magnetic resonance imaging (MRI) to guide placement of a safe, non-invasive magnetic coil over a specific brain area called the supplementary motor area, followed by walking exercises that include thinking tasks; sessions are videotaped and measured with small motion sensors. Everyone in the study receives the same intervention rather than a placebo, and using this brain stimulation for freezing of gait is considered investigational. The study at the Medical University of South Carolina is enrolling up to 15 people aged 50 to 80 who have Parkinson's with freezing of gait, have not changed Parkinson's medications in the past month, and can complete walking tests without assistance.
Locations
- Medical University of South Carlina, Charleston, South Carolina, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying TMS+ Gait training. The goal is to learn whether a personalized form of repeated magnetic brain stimulation, given with walking practice, is practical and tolerable and shows early signs of helping people with Parkinson's who experience freezing of gait, the sudden feeling of being stuck when trying to walk. The approach uses magnetic resonance imaging (MRI) to guide placement of a safe, non-invasive magnetic coil over a specific brain area called the supplementary motor area, followed by walking exercises that include thinking tasks; sessions are videotaped and measured with small motion sensors. Everyone in the study receives the same intervention rather than a placebo, and using this brain stimulation for freezing of gait is considered investigational. The study at the Medical University of South Carolina is enrolling up to 15 people aged 50 to 80 who have Parkinson's with freezing of gait, have not changed Parkinson's medications in the past month, and can complete walking tests without assistance.
- Who can participate?
- Participants must be between 50 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 2 years and 1 month.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- Everyone in this trial receives the experimental treatment. There is no placebo group.
- How many visits does this trial involve?
- You will attend up to 15 study visits over about 16 weeks.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: MRI scan (non-invasive); Questionnaires & surveys (non-invasive). Confirm the full schedule with the study coordinator.