Timed stimulation reduces hand tremor
- Trial ID
- NCT06993571
- Official Title
- Closed-loop Phase-adaptive Cerebellar Transcranial Alternating Current Stimulation (tACS) to Modulate Activity in the Cerebello-thalamo-cortical Network to Reduce Parkinson's Disease Tremor
- Goal
- Timed stimulation reduces hand tremor
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
- Study Type
- INTERVENTIONAL
- Enrollment
- 10 participants
- Conditions
- Parkinson's Disease (PD), Tremor
- Interventions
- Active-tACS, Sham-tACS, Unlocked-tACS
Plain-Language Summary
The goal is to reduce moderate to severe hand tremor in Parkinson's by changing activity in the cerebello-thalamo-cortical network that helps generate tremor rhythms. The approach uses noninvasive transcranial alternating current stimulation over the cerebellum, delivering weak electrical currents timed to a person’s tremor in a closed-loop, phase-adaptive way to disrupt the abnormal rhythmic brain activity that drives tremor, and because it is non-drug it can be given alongside usual medications like levodopa. Participants may be randomized to active phase-locked tACS, sham tACS, or unlocked tACS that is not phase-locked, so researchers can test whether syncing stimulation to tremor timing matters. The trial is looking for adults 18 and older with a UK Brain Bank diagnosis of Parkinson's and moderate to severe hand tremor who can consent, while excluding people with pacemakers or metal implants, other major neurological or psychiatric disorders, or pregnancy.
Locations
- Universitätsklinikum Hamburg-Eppendorf, Hamburg, Free and Hanseatic City of Hamburg, Germany
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Active-tACS. The goal is to reduce moderate to severe hand tremor in Parkinson's by changing activity in the cerebello-thalamo-cortical network that helps generate tremor rhythms. The approach uses noninvasive transcranial alternating current stimulation over the cerebellum, delivering weak electrical currents timed to a person’s tremor in a closed-loop, phase-adaptive way to disrupt the abnormal rhythmic brain activity that drives tremor, and because it is non-drug it can be given alongside usual medications like levodopa. Participants may be randomized to active phase-locked tACS, sham tACS, or unlocked tACS that is not phase-locked, so researchers can test whether syncing stimulation to tremor timing matters. The trial is looking for adults 18 and older with a UK Brain Bank diagnosis of Parkinson's and moderate to severe hand tremor who can consent, while excluding people with pacemakers or metal implants, other major neurological or psychiatric disorders, or pregnancy.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 7 months.