Improve ability to stop actions
- Trial ID
- NCT07022522
- Official Title
- Frequency-dependent Modulation of Inhibitory Control Via Subthalamic Nucleus Subregional Stimulation in Parkinson's Disease
- Goal
- Improve ability to stop actions
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Beijing Tiantan Hospital
- Study Type
- INTERVENTIONAL
- Enrollment
- 20 participants
- Conditions
- Parkinson Disease, Deep Brain Stimulation
- Interventions
- 5Hz stimulation on the STN motor subregion, 5Hz stimulation on the STN associative subregion, 130Hz stimulation on the STN motor subregion, 130Hz stimulation on the STN associative subregion, No stimulation
Plain-Language Summary
The goal is to learn how changing the frequency and exact spot of deep brain stimulation in the subthalamic nucleus affects inhibitory control, meaning the ability to stop or suppress actions that can be harder with Parkinson's. Researchers will apply brief electrical pulses to either the STN motor or associative subregion at low frequency (5 Hz) or high frequency (130 Hz), or leave stimulation off, and compare how those settings change stopping ability; high-frequency STN stimulation generally suppresses abnormal motor firing, while low-frequency pulses can recruit different circuits that may alter cognitive control and impulsivity. The trial is looking for people 40 to 80 years old with idiopathic Parkinson's who meet indications for DBS surgery, excluding those with major psychiatric illness or dementia, significant post-DBS complications, or sensory problems that would affect the cognitive tests.
Locations
- Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing Municipality, China
Frequently Asked Questions
- What is this trial testing?
- This trial is studying 5Hz stimulation on the STN motor subregion. The goal is to learn how changing the frequency and exact spot of deep brain stimulation in the subthalamic nucleus affects inhibitory control, meaning the ability to stop or suppress actions that can be harder with Parkinson's. Researchers will apply brief electrical pulses to either the STN motor or associative subregion at low frequency (5 Hz) or high frequency (130 Hz), or leave stimulation off, and compare how those settings change stopping ability; high-frequency STN stimulation generally suppresses abnormal motor firing, while low-frequency pulses can recruit different circuits that may alter cognitive control and impulsivity. The trial is looking for people 40 to 80 years old with idiopathic Parkinson's who meet indications for DBS surgery, excluding those with major psychiatric illness or dementia, significant post-DBS complications, or sensory problems that would affect the cognitive tests.
- Who can participate?
- Participants must be between 40 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 4 months.