Predict Parkinson progression using neuroimaging
- Trial ID
- NCT07024875
- Official Title
- Precision Neuroimaging of Parkinson's Disease
- Goal
- Predict Parkinson progression using neuroimaging
- Status
- RECRUITING
- Sponsor
- Washington University School of Medicine
- Study Type
- OBSERVATIONAL
- Enrollment
- 120 participants
- Conditions
- Parkinsons Disease (PD)
Summary For Families
The goal is to use high-precision MRI to identify brain markers that track Parkinson's progression and link specific brain changes to motor and cognitive symptoms, so diagnosis and care can be more personalized. The approach is non-invasive advanced neuroimaging, using structural and functional MRI to map brain anatomy and activity patterns; the scans do not change your medications or interact with levodopa, they just let researchers see how brain circuits relate to symptoms. They are enrolling adults 50 and older with a clinical diagnosis of Parkinson's who do not meet criteria for dementia, plus healthy volunteers with normal cognition and no first-degree relatives with PD, and they exclude people with other neurological or serious medical or psychiatric conditions, major head injury, or MRI contraindications like metal implants or claustrophobia.
Locations
- East Imaging Building, St Louis, Missouri, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying an experimental treatment. The goal is to use high-precision MRI to identify brain markers that track Parkinson's progression and link specific brain changes to motor and cognitive symptoms, so diagnosis and care can be more personalized. The approach is non-invasive advanced neuroimaging, using structural and functional MRI to map brain anatomy and activity patterns; the scans do not change your medications or interact with levodopa, they just let researchers see how brain circuits relate to symptoms. They are enrolling adults 50 and older with a clinical diagnosis of Parkinson's who do not meet criteria for dementia, plus healthy volunteers with normal cognition and no first-degree relatives with PD, and they exclude people with other neurological or serious medical or psychiatric conditions, major head injury, or MRI contraindications like metal implants or claustrophobia.
- Who can participate?
- Participants must be at least 40 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 5 years and 5 months.
- Will I get the real drug or a placebo?
- It depends on the trial design. Some Parkinson's trials are placebo controlled, meaning a portion of participants get an inactive comparison while others get the experimental treatment. Some use crossover designs so everyone eventually receives the active treatment at some point. Observational trials do not use a placebo at all because they are not testing a new treatment. The consent form for any specific trial spells out the design and your odds of being assigned to placebo before you enroll.
- How often will I need to visit the study site?
- Visit frequency varies by trial. Many Parkinson's studies require an in person visit every 4 to 12 weeks during the active treatment phase, with shorter or longer gaps depending on the design. The site coordinator can give you the full visit schedule before you sign anything, so you know what the time commitment looks like.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Will travel or parking be reimbursed?
- Many trials reimburse for parking, mileage, and sometimes lodging if the site is far from your home. Reimbursement policies vary by sponsor and site. When you contact the trial team, ask specifically what is covered and how reimbursement is processed.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.