Parkinson's Trial NCT07024875
Predict Parkinson progression using neuroimaging
- Trial ID
- NCT07024875
- Official Title
- Precision Neuroimaging of Parkinson's Disease
- Goal
- Predict Parkinson progression using neuroimaging
- Status
- RECRUITING
- Sponsor
- Washington University School of Medicine
- Study Type
- OBSERVATIONAL
- Enrollment
- 120 participants
- Conditions
- Parkinsons Disease (PD)
Summary For Families
The goal is to use high-precision MRI to identify brain markers that track Parkinson's progression and link specific brain changes to motor and cognitive symptoms, so diagnosis and care can be more personalized. The approach is non-invasive advanced neuroimaging, using structural and functional MRI to map brain anatomy and activity patterns; the scans do not change your medications or interact with levodopa, they just let researchers see how brain circuits relate to symptoms. They are enrolling adults 50 and older with a clinical diagnosis of Parkinson's who do not meet criteria for dementia, plus healthy volunteers with normal cognition and no first-degree relatives with PD, and they exclude people with other neurological or serious medical or psychiatric conditions, major head injury, or MRI contraindications like metal implants or claustrophobia.
Locations
- East Imaging Building, St Louis, Missouri, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying an experimental treatment. The goal is to use high-precision MRI to identify brain markers that track Parkinson's progression and link specific brain changes to motor and cognitive symptoms, so diagnosis and care can be more personalized. The approach is non-invasive advanced neuroimaging, using structural and functional MRI to map brain anatomy and activity patterns; the scans do not change your medications or interact with levodopa, they just let researchers see how brain circuits relate to symptoms. They are enrolling adults 50 and older with a clinical diagnosis of Parkinson's who do not meet criteria for dementia, plus healthy volunteers with normal cognition and no first-degree relatives with PD, and they exclude people with other neurological or serious medical or psychiatric conditions, major head injury, or MRI contraindications like metal implants or claustrophobia.
- Who can participate?
- Participants must be at least 40 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 5 years and 5 months.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- This is an observational study, so there is no placebo and no experimental treatment is assigned. Researchers observe and collect information while you continue your usual care.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: Brain surgery / implanted device (invasive); MRI scan (non-invasive). Confirm the full schedule with the study coordinator.