Improve sleep using brain pulses
- Trial ID
- NCT07110376
- Official Title
- Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease - The DREAMS-PD Study
- Goal
- Improve sleep using brain pulses
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- The Cleveland Clinic
- Study Type
- INTERVENTIONAL
- Enrollment
- 10 participants
- Conditions
- Parkinson Disease
- Interventions
- Nighttime Deep Brain Stimulation with Varying Amplitude Settings
Plain-Language Summary
The DREAMS-PD team wants to know whether changing the amplitude of overnight deep brain stimulation changes brain activity during sleep and may affect overnight symptoms like movement or sleep quality. They will use the Medtronic Percept PC, which delivers electrical pulses to the subthalamic nucleus to calm abnormal Parkinson's-related brain rhythms and also records local brain signals; by varying the stimulation amplitude at night they can see how different settings alter sleep-related neural patterns while keeping daytime therapy and medications stable. Adults over 18 with idiopathic Parkinson's who already have bilateral Percept PC STN implants with settings optimized for at least three months, report some sleep problems, can walk independently, do not have dementia or untreated significant sleep apnea, and keep sleep medications stable are eligible.
Locations
- Cleveland Clinic, Cleveland, Ohio, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Nighttime Deep Brain Stimulation with Varying Amplitude Settings. The DREAMS-PD team wants to know whether changing the amplitude of overnight deep brain stimulation changes brain activity during sleep and may affect overnight symptoms like movement or sleep quality. They will use the Medtronic Percept PC, which delivers electrical pulses to the subthalamic nucleus to calm abnormal Parkinson's-related brain rhythms and also records local brain signals; by varying the stimulation amplitude at night they can see how different settings alter sleep-related neural patterns while keeping daytime therapy and medications stable. Adults over 18 with idiopathic Parkinson's who already have bilateral Percept PC STN implants with settings optimized for at least three months, report some sleep problems, can walk independently, do not have dementia or untreated significant sleep apnea, and keep sleep medications stable are eligible.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 7 months.