Percept™ PC and Percept RC with Ad… for Parkinson's (NCT07216976)
Adaptive stimulation improves motor control
- Trial ID
- NCT07216976
- Official Title
- Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) China Study
- Goal
- Adaptive stimulation improves motor control
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- MedtronicNeuro
- Study Type
- INTERVENTIONAL
- Enrollment
- 62 participants
- Conditions
- Parkinson's Disease
- Interventions
- Percept™ PC and Percept RC with Adaptive DBS (aDBS™)
Summary For Families
The goal is to make deep brain stimulation more personalized so motor symptoms are better controlled with fewer side effects, by using the brain's own signals to guide when and how much stimulation is delivered. It uses Medtronic's Percept PC with an adaptive DBS algorithm that senses alpha‑beta local field potentials (8 to 30 Hz) from STN or GPi leads and automatically raises or lowers stimulation in real time, working alongside your current Parkinson medications and clinician settings rather than replacing them. Looking for adults 18 and older who already have a Percept PC and compatible bilateral STN or GPi leads, who respond to DBS and have stable medications and stimulation, and who show detectable alpha‑beta signals on screening; people with major depression, incompatible or extra implanted devices, low INS battery life, pregnancy or breastfeeding, or inability to use the patient programmer are excluded.
Locations
- Xuanwu Hospital, Beijing, Beijing Municipality, China
- Sun Yat-sen Hospital, Guangzhou, Guangdong, China
- Huashan Hospital, Shanghai, Shanghai Municipality, China
- Ruijin Hospital, Shanghai, Shanghai Municipality, China
- West China Hospital, Chengdu, Sichuan, China
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Percept™ PC and Percept RC with Adaptive DBS (aDBS™). The goal is to make deep brain stimulation more personalized so motor symptoms are better controlled with fewer side effects, by using the brain's own signals to guide when and how much stimulation is delivered. It uses Medtronic's Percept PC with an adaptive DBS algorithm that senses alpha‑beta local field potentials (8 to 30 Hz) from STN or GPi leads and automatically raises or lowers stimulation in real time, working alongside your current Parkinson medications and clinician settings rather than replacing them. Looking for adults 18 and older who already have a Percept PC and compatible bilateral STN or GPi leads, who respond to DBS and have stable medications and stimulation, and who show detectable alpha‑beta signals on screening; people with major depression, incompatible or extra implanted devices, low INS battery life, pregnancy or breastfeeding, or inability to use the patient programmer are excluded.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 5 locations.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 1 month.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- Everyone in this trial receives the experimental treatment. There is no placebo group.