Adaptive stimulation improves motor control
- Trial ID
- NCT07216976
- Official Title
- Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) China Study
- Goal
- Adaptive stimulation improves motor control
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- MedtronicNeuro
- Study Type
- INTERVENTIONAL
- Enrollment
- 62 participants
- Conditions
- Parkinson's Disease
- Interventions
- Percept™ PC and Percept RC with Adaptive DBS (aDBS™)
Summary For Families
The goal is to make deep brain stimulation more personalized so motor symptoms are better controlled with fewer side effects, by using the brain's own signals to guide when and how much stimulation is delivered. It uses Medtronic's Percept PC with an adaptive DBS algorithm that senses alpha‑beta local field potentials (8 to 30 Hz) from STN or GPi leads and automatically raises or lowers stimulation in real time, working alongside your current Parkinson medications and clinician settings rather than replacing them. Looking for adults 18 and older who already have a Percept PC and compatible bilateral STN or GPi leads, who respond to DBS and have stable medications and stimulation, and who show detectable alpha‑beta signals on screening; people with major depression, incompatible or extra implanted devices, low INS battery life, pregnancy or breastfeeding, or inability to use the patient programmer are excluded.
Locations
- Xuanwu Hospital, Beijing, Beijing Municipality, China
- Sun Yat-sen Hospital, Guangzhou, Guangdong, China
- Huashan Hospital, Shanghai, Shanghai Municipality, China
- Ruijin Hospital, Shanghai, Shanghai Municipality, China
- West China Hospital, Chengdu, Sichuan, China
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Percept™ PC and Percept RC with Adaptive DBS (aDBS™). The goal is to make deep brain stimulation more personalized so motor symptoms are better controlled with fewer side effects, by using the brain's own signals to guide when and how much stimulation is delivered. It uses Medtronic's Percept PC with an adaptive DBS algorithm that senses alpha‑beta local field potentials (8 to 30 Hz) from STN or GPi leads and automatically raises or lowers stimulation in real time, working alongside your current Parkinson medications and clinician settings rather than replacing them. Looking for adults 18 and older who already have a Percept PC and compatible bilateral STN or GPi leads, who respond to DBS and have stable medications and stimulation, and who show detectable alpha‑beta signals on screening; people with major depression, incompatible or extra implanted devices, low INS battery life, pregnancy or breastfeeding, or inability to use the patient programmer are excluded.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 5 locations.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 1 month.
- Will I get the real drug or a placebo?
- It depends on the trial design. Some Parkinson's trials are placebo controlled, meaning a portion of participants get an inactive comparison while others get the experimental treatment. Some use crossover designs so everyone eventually receives the active treatment at some point. Observational trials do not use a placebo at all because they are not testing a new treatment. The consent form for any specific trial spells out the design and your odds of being assigned to placebo before you enroll.
- How often will I need to visit the study site?
- Visit frequency varies by trial. Many Parkinson's studies require an in person visit every 4 to 12 weeks during the active treatment phase, with shorter or longer gaps depending on the design. The site coordinator can give you the full visit schedule before you sign anything, so you know what the time commitment looks like.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Will travel or parking be reimbursed?
- Many trials reimburse for parking, mileage, and sometimes lodging if the site is far from your home. Reimbursement policies vary by sponsor and site. When you contact the trial team, ask specifically what is covered and how reimbursement is processed.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.