Parkinson's Trial NCT07299448
Identify neural causes of dysphagia
- Trial ID
- NCT07299448
- Official Title
- Biological Determinants and Neural Compensatory Mechanisms of Oropharyngeal Dysphagia in Parkinson's Disease
- Goal
- Identify neural causes of dysphagia
- Status
- RECRUITING
- Sponsor
- Heinrich-Heine University, Duesseldorf
- Study Type
- OBSERVATIONAL
- Enrollment
- 100 participants
- Conditions
- Parkinsons Disease (PD), Oropharyngeal Dysphagia
Summary For Families
They want to pin down the biological factors and brain compensation patterns that lead to or protect against oropharyngeal dysphagia, the swallowing problems many people with Parkinson's can develop. As an observational study, researchers will use brain MRI, cough reflex and throat-sensation tests, and clinical swallowing assessments to map how sensory loss and altered neural networks relate to swallowing function, they are measuring how the body and brain behave rather than testing a treatment. Adults 18 and older with idiopathic Parkinson's at any disease stage who can eat orally and follow the testing can join, while people with other causes of dysphagia, implanted electronic stimulators or MRI contraindications, or asthma/COPD are excluded.
Locations
- University Hospital Düsseldorf, Düsseldorf, North Rhine-Westphalia, Germany
Frequently Asked Questions
- What is this trial testing?
- This trial is studying an experimental treatment. They want to pin down the biological factors and brain compensation patterns that lead to or protect against oropharyngeal dysphagia, the swallowing problems many people with Parkinson's can develop. As an observational study, researchers will use brain MRI, cough reflex and throat-sensation tests, and clinical swallowing assessments to map how sensory loss and altered neural networks relate to swallowing function, they are measuring how the body and brain behave rather than testing a treatment. Adults 18 and older with idiopathic Parkinson's at any disease stage who can eat orally and follow the testing can join, while people with other causes of dysphagia, implanted electronic stimulators or MRI contraindications, or asthma/COPD are excluded.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 2 years.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- This is an observational study, so there is no placebo and no experimental treatment is assigned. Researchers observe and collect information while you continue your usual care.
- How many visits does this trial involve?
- All participants will undergo three examination blocks.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: MRI scan (non-invasive); Thinking & memory tests (non-invasive). Confirm the full schedule with the study coordinator.