Improve walking and movement control
- Trial ID
- NCT07309198
- Official Title
- Effects and Mechanisms of Non-invasive Deep Brain Stimulation in Patients With Parkinson's Disease
- Goal
- Improve walking and movement control
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Shanghai University of Sport
- Study Type
- INTERVENTIONAL
- Enrollment
- 36 participants
- Conditions
- Parkinson's Disease
- Interventions
- Transcranial Temporal Interference Stimulation (TIS)
Plain-Language Summary
They want to see whether noninvasive deep brain stimulation can change the deep motor circuits that drive Parkinson's movement problems and to learn how those changes happen. The method, transcranial temporal interference stimulation, sends two high-frequency electric fields that overlap to produce a low-frequency signal deep in the brain, modulating activity in targets like the basal ganglia without directly stimulating the scalp, and it is tested while participants keep their usual Parkinsons meds unchanged. Looking for people aged 50 to 80 with physician-diagnosed idiopathic Parkinsons, Hoehn and Yahr stages 1.5 to 3 who can walk unassisted, on a stable antiparkinsonian regimen for at least 4 weeks, and with MoCA of 21 or higher. People with MRI or stimulation contraindications, prior DBS, current antipsychotic or antidepressant use, major psychiatric illness, certain cardiovascular or orthopedic risks are excluded.
Locations
- Shanghai University of Sport, Shanghai, Shanghai Municipality, China
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Transcranial Temporal Interference Stimulation (TIS). They want to see whether noninvasive deep brain stimulation can change the deep motor circuits that drive Parkinson's movement problems and to learn how those changes happen. The method, transcranial temporal interference stimulation, sends two high-frequency electric fields that overlap to produce a low-frequency signal deep in the brain, modulating activity in targets like the basal ganglia without directly stimulating the scalp, and it is tested while participants keep their usual Parkinsons meds unchanged. Looking for people aged 50 to 80 with physician-diagnosed idiopathic Parkinsons, Hoehn and Yahr stages 1.5 to 3 who can walk unassisted, on a stable antiparkinsonian regimen for at least 4 weeks, and with MoCA of 21 or higher. People with MRI or stimulation contraindications, prior DBS, current antipsychotic or antidepressant use, major psychiatric illness, certain cardiovascular or orthopedic risks are excluded.
- Who can participate?
- Participants must be between 50 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 3 months.