Parkinson's Trial NCT07353463
Track disease progression in Parkinson
- Trial ID
- NCT07353463
- Official Title
- Shanghai Clinical Cohort - Parkinson's Disease (Reserve)
- Goal
- Track disease progression in Parkinson
- Status
- RECRUITING
- Sponsor
- Ruijin Hospital
- Study Type
- OBSERVATIONAL
- Enrollment
- 700 participants
- Conditions
- Parkinson's Disease (PD), Multiple System Atrophy
Summary For Families
The goal is to build a large Shanghai cohort to find fluid and imaging biomarkers that help distinguish Parkinson's disease from multiple system atrophy and to track how each condition progresses. Participants give blood, saliva and optionally cerebrospinal fluid, and have MRI and PET/SPECT scans plus detailed motor and nonmotor assessments so researchers can link protein markers, genetics, and brain imaging patterns to symptoms and progression. The protocol is observational, so usual treatments like levodopa are not changed while data are collected. Eligible are adults diagnosed with PD by the Chinese 2016 criteria or clinically probable MSA by the 2022 consensus who can give informed consent and tolerate samples and imaging; people with unclear diagnoses, major brain lesions, severe psychiatric illness, serious organ failure, or inability to complete assessments are excluded.
Locations
- Department of neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Frequently Asked Questions
- What is this trial testing?
- This trial is studying an experimental treatment. The goal is to build a large Shanghai cohort to find fluid and imaging biomarkers that help distinguish Parkinson's disease from multiple system atrophy and to track how each condition progresses. Participants give blood, saliva and optionally cerebrospinal fluid, and have MRI and PET/SPECT scans plus detailed motor and nonmotor assessments so researchers can link protein markers, genetics, and brain imaging patterns to symptoms and progression. The protocol is observational, so usual treatments like levodopa are not changed while data are collected. Eligible are adults diagnosed with PD by the Chinese 2016 criteria or clinically probable MSA by the 2022 consensus who can give informed consent and tolerate samples and imaging; people with unclear diagnoses, major brain lesions, severe psychiatric illness, serious organ failure, or inability to complete assessments are excluded.
- Who can participate?
- Eligibility criteria vary. Check the full listing on ClinicalTrials.gov for detailed inclusion and exclusion criteria.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 9 months.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- This is an observational study, so there is no placebo and no experimental treatment is assigned. Researchers observe and collect information while you continue your usual care.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: MRI scan (non-invasive); Brain wave recording (EEG) (non-invasive). Confirm the full schedule with the study coordinator.