Track disease progression in Parkinson
- Trial ID
- NCT07353463
- Official Title
- Shanghai Clinical Cohort - Parkinson's Disease (Reserve)
- Goal
- Track disease progression in Parkinson
- Status
- RECRUITING
- Sponsor
- Ruijin Hospital
- Study Type
- OBSERVATIONAL
- Enrollment
- 700 participants
- Conditions
- Parkinson's Disease (PD), Multiple System Atrophy
Summary For Families
The goal is to build a large Shanghai cohort to find fluid and imaging biomarkers that help distinguish Parkinson's disease from multiple system atrophy and to track how each condition progresses. Participants give blood, saliva and optionally cerebrospinal fluid, and have MRI and PET/SPECT scans plus detailed motor and nonmotor assessments so researchers can link protein markers, genetics, and brain imaging patterns to symptoms and progression. The protocol is observational, so usual treatments like levodopa are not changed while data are collected. Eligible are adults diagnosed with PD by the Chinese 2016 criteria or clinically probable MSA by the 2022 consensus who can give informed consent and tolerate samples and imaging; people with unclear diagnoses, major brain lesions, severe psychiatric illness, serious organ failure, or inability to complete assessments are excluded.
Locations
- Department of neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Frequently Asked Questions
- What is this trial testing?
- This trial is studying an experimental treatment. The goal is to build a large Shanghai cohort to find fluid and imaging biomarkers that help distinguish Parkinson's disease from multiple system atrophy and to track how each condition progresses. Participants give blood, saliva and optionally cerebrospinal fluid, and have MRI and PET/SPECT scans plus detailed motor and nonmotor assessments so researchers can link protein markers, genetics, and brain imaging patterns to symptoms and progression. The protocol is observational, so usual treatments like levodopa are not changed while data are collected. Eligible are adults diagnosed with PD by the Chinese 2016 criteria or clinically probable MSA by the 2022 consensus who can give informed consent and tolerate samples and imaging; people with unclear diagnoses, major brain lesions, severe psychiatric illness, serious organ failure, or inability to complete assessments are excluded.
- Who can participate?
- Eligibility criteria vary. Check the full listing on ClinicalTrials.gov for detailed inclusion and exclusion criteria.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 9 months.
- Will I get the real drug or a placebo?
- It depends on the trial design. Some Parkinson's trials are placebo controlled, meaning a portion of participants get an inactive comparison while others get the experimental treatment. Some use crossover designs so everyone eventually receives the active treatment at some point. Observational trials do not use a placebo at all because they are not testing a new treatment. The consent form for any specific trial spells out the design and your odds of being assigned to placebo before you enroll.
- How often will I need to visit the study site?
- Visit frequency varies by trial. Many Parkinson's studies require an in person visit every 4 to 12 weeks during the active treatment phase, with shorter or longer gaps depending on the design. The site coordinator can give you the full visit schedule before you sign anything, so you know what the time commitment looks like.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Will travel or parking be reimbursed?
- Many trials reimburse for parking, mileage, and sometimes lodging if the site is far from your home. Reimbursement policies vary by sponsor and site. When you contact the trial team, ask specifically what is covered and how reimbursement is processed.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.