Low-Load Resistance Training for Parkinson's (NCT07378813)
Improve walking using resistance training
- Trial ID
- NCT07378813
- Official Title
- Comparison of Changes in Neuromuscular and Functional Performance Due to Resistance Training With Low-Load or High-Load in Persons With Parkinson's Disease.
- Goal
- Improve walking using resistance training
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University of Miami
- Study Type
- INTERVENTIONAL
- Enrollment
- 60 participants
- Conditions
- Activity, Motor
- Interventions
- Low-Load Resistance Training, High-Load Resistance Training
Summary For Families
The goal is to find whether low-load or high-load resistance training better improves muscle strength, power, and everyday mobility in people with early to mid-stage Parkinson's. Participants will follow supervised weight programs using either lighter weights with higher reps to build muscle endurance and motor control, or heavier weights with lower reps to build strength and power, with the idea that stronger leg and core muscles can improve gait, balance, and transfers. The program is done alongside usual medical care, so it does not replace medications like levodopa and may help medications work better by improving overall movement and functional reserve. They plan to enroll 60 people aged 50 to 85 with Parkinson's at Hoehn and Yahr stages 1 to 3 who can walk 50 meters unassisted and have a MoCA above 18, excluding those with uncontrolled cardiovascular or neuromuscular disease, systemic inflammatory or autoimmune conditions, or unresolved limb injuries that prevent weight training.
Locations
- Laboratory of Neruomuscular Research and Active Aging, Coral Gables, Florida, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Low-Load Resistance Training. The goal is to find whether low-load or high-load resistance training better improves muscle strength, power, and everyday mobility in people with early to mid-stage Parkinson's. Participants will follow supervised weight programs using either lighter weights with higher reps to build muscle endurance and motor control, or heavier weights with lower reps to build strength and power, with the idea that stronger leg and core muscles can improve gait, balance, and transfers. The program is done alongside usual medical care, so it does not replace medications like levodopa and may help medications work better by improving overall movement and functional reserve. They plan to enroll 60 people aged 50 to 85 with Parkinson's at Hoehn and Yahr stages 1 to 3 who can walk 50 meters unassisted and have a MoCA above 18, excluding those with uncontrolled cardiovascular or neuromuscular disease, systemic inflammatory or autoimmune conditions, or unresolved limb injuries that prevent weight training.
- Who can participate?
- Participants must be between 50 Years and 85 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 4 months.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- There is no placebo group. Everyone receives an active treatment; the study compares one treatment against another.
- How many visits does this trial involve?
- Training is twice per week for at least 24 sessions over up to 12 weeks.