Improve walking using resistance training
- Trial ID
- NCT07378813
- Official Title
- Comparison of Changes in Neuromuscular and Functional Performance Due to Resistance Training With Low-Load or High-Load in Persons With Parkinson's Disease.
- Goal
- Improve walking using resistance training
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University of Miami
- Study Type
- INTERVENTIONAL
- Enrollment
- 60 participants
- Conditions
- Activity, Motor
- Interventions
- Low-Load Resistance Training, High-Load Resistance Training
Summary For Families
The goal is to find whether low-load or high-load resistance training better improves muscle strength, power, and everyday mobility in people with early to mid-stage Parkinson's. Participants will follow supervised weight programs using either lighter weights with higher reps to build muscle endurance and motor control, or heavier weights with lower reps to build strength and power, with the idea that stronger leg and core muscles can improve gait, balance, and transfers. The program is done alongside usual medical care, so it does not replace medications like levodopa and may help medications work better by improving overall movement and functional reserve. They plan to enroll 60 people aged 50 to 85 with Parkinson's at Hoehn and Yahr stages 1 to 3 who can walk 50 meters unassisted and have a MoCA above 18, excluding those with uncontrolled cardiovascular or neuromuscular disease, systemic inflammatory or autoimmune conditions, or unresolved limb injuries that prevent weight training.
Locations
- Laboratory of Neruomuscular Research and Active Aging, Coral Gables, Florida, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Low-Load Resistance Training. The goal is to find whether low-load or high-load resistance training better improves muscle strength, power, and everyday mobility in people with early to mid-stage Parkinson's. Participants will follow supervised weight programs using either lighter weights with higher reps to build muscle endurance and motor control, or heavier weights with lower reps to build strength and power, with the idea that stronger leg and core muscles can improve gait, balance, and transfers. The program is done alongside usual medical care, so it does not replace medications like levodopa and may help medications work better by improving overall movement and functional reserve. They plan to enroll 60 people aged 50 to 85 with Parkinson's at Hoehn and Yahr stages 1 to 3 who can walk 50 meters unassisted and have a MoCA above 18, excluding those with uncontrolled cardiovascular or neuromuscular disease, systemic inflammatory or autoimmune conditions, or unresolved limb injuries that prevent weight training.
- Who can participate?
- Participants must be between 50 Years and 85 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 4 months.
- Will I get the real drug or a placebo?
- It depends on the trial design. Some Parkinson's trials are placebo controlled, meaning a portion of participants get an inactive comparison while others get the experimental treatment. Some use crossover designs so everyone eventually receives the active treatment at some point. Observational trials do not use a placebo at all because they are not testing a new treatment. The consent form for any specific trial spells out the design and your odds of being assigned to placebo before you enroll.
- How often will I need to visit the study site?
- Visit frequency varies by trial. Many Parkinson's studies require an in person visit every 4 to 12 weeks during the active treatment phase, with shorter or longer gaps depending on the design. The site coordinator can give you the full visit schedule before you sign anything, so you know what the time commitment looks like.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Will travel or parking be reimbursed?
- Many trials reimburse for parking, mileage, and sometimes lodging if the site is far from your home. Reimbursement policies vary by sponsor and site. When you contact the trial team, ask specifically what is covered and how reimbursement is processed.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.