Reduce tremor and improve gait
- Trial ID
- NCT07384442
- Official Title
- Effects of Targeted Temporal Interference Stimulation of Cerebellar Nuclei on Tremor and Gait Disturbance in Parkinson's Disease Patients
- Goal
- Reduce tremor and improve gait
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- YangPan
- Study Type
- INTERVENTIONAL
- Enrollment
- 50 participants
- Conditions
- Parkinson's Disease, Movement Disorders
- Interventions
- Sham Temporal Interference Stimulation, Real Temporal Interference Stimulation
Plain-Language Summary
The goal is to reduce tremor and improve walking and balance by calming abnormal activity in the cerebellar nuclei that can worsen those problems in Parkinson's. The team uses targeted temporal interference stimulation, a noninvasive electrical method that sends two high-frequency currents through the skull so they interfere and create a low-frequency signal deep in the cerebellar nuclei, modulating their output to try to lessen tremor and improve gait while participants continue their usual levodopa rather than replace it. They are looking for people 50 or older with idiopathic Parkinson's for at least two years who have tremor and gait disturbance, respond to levodopa, have had stable medications for four weeks, can walk independently for five minutes, and do not have major cognitive impairment, recent neuromodulation, or metal implants like DBS or a pacemaker.
Locations
- Zhongnan hospital, Wuhan, Hubei, China
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Sham Temporal Interference Stimulation. The goal is to reduce tremor and improve walking and balance by calming abnormal activity in the cerebellar nuclei that can worsen those problems in Parkinson's. The team uses targeted temporal interference stimulation, a noninvasive electrical method that sends two high-frequency currents through the skull so they interfere and create a low-frequency signal deep in the cerebellar nuclei, modulating their output to try to lessen tremor and improve gait while participants continue their usual levodopa rather than replace it. They are looking for people 50 or older with idiopathic Parkinson's for at least two years who have tremor and gait disturbance, respond to levodopa, have had stable medications for four weeks, can walk independently for five minutes, and do not have major cognitive impairment, recent neuromodulation, or metal implants like DBS or a pacemaker.
- Who can participate?
- Participants must be at least 50 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 9 months.