Medtronic Percept Deep Brain Stimu… for Parkinson's (NCT07398157)
Personalize brain stimulation for movement
- Trial ID
- NCT07398157
- Official Title
- Subgaleal Cortical Electrodes in Patients With Parkinson's Disease Undergoing Deep-brain Stimulation Therapy for Sensing and Adaptive Deep-brain Stimulation Over a 24-hour Period.
- Goal
- Personalize brain stimulation for movement
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University of California, San Francisco
- Study Type
- INTERVENTIONAL
- Enrollment
- 24 participants
- Conditions
- PD - Parkinson's Disease
- Interventions
- Medtronic Percept Deep Brain Stimulation (cDBS), Medtronic Percept Deep Brain Stimulation (daytime aDBS), Medtronic Percept Deep Brain Stimulation (nighttime aDBS)
- Registry Record Last Updated
- 2026-05-05 (2 months ago)
- Estimated Commitment
- Moderate commitment estimated from the protocol (based on: invasive procedure). This reflects time and procedures only — confirm details with the study coordinator.
Summary For Families
They are testing whether adding thin sensing electrodes under the scalp can let deep-brain stimulation adjust itself over a full 24 hours to reduce daytime off periods, troublesome dyskinesias, and sleep-related problems. The Medtronic Percept system records cortical rhythms from the subgaleal electrodes and runs closed-loop adaptive DBS that increases stimulation when brain signals predict an off state or motor symptoms and reduces stimulation during good on periods or sleep, so it is designed to work alongside levodopa rather than replace it. Adults 25 to 75 with idiopathic Parkinson's who are DBS candidates, have motor fluctuations despite optimized medications with at least two hours per day of off time or on time with dyskinesias, a normal brain MRI, and preserved cognition (MoCA 24 or higher) are being recruited. People with major medical or psychiatric risks, MR-incompatible implants, or other surgical contraindications are excluded, and about 24 participants will be enrolled.
Eligibility at a Glance
Key requirements found in this trial's official criteria, in plain language. Only what the listing states is shown; the study team makes the final call.
- Levodopa: Must be taking levodopa (criteria text: "motor updrs-iii off medication score 25 to 65 and a >35% improvement with levodopa, predominant rigid/bradykinetic symptoms (ratio of off-medication updrs-ii...")
- Motor fluctuations: Must have motor fluctuations (off periods when medication wears off) (criteria text: "Motor fluctuations despite optimized medical therapy with at least 2 hours per day of either "off" time, or "on" with dyskinesias.")
- Dyskinesia: Must have dyskinesia (involuntary movements) (criteria text: "motor fluctuations despite optimized medical therapy with at least 2 hours per day of either "off" time, or "on" with dyskinesias")
- Deep brain stimulation: Must already have a DBS device (deep brain stimulation)
- Thinking test (MoCA): MoCA memory and thinking score of at least 24 (criteria text: "Absence of significant cognitive impairment (score of 24 or greater on the Montreal Cognitive Assessment (MoCA).")
- Movement score (MDS-UPDRS): MDS-UPDRS movement score of at least 36 (criteria text: "motor updrs-iii off medication score 25 to 65 and a >35% improvement with levodopa, predominant rigid/bradykinetic symptoms (ratio of off-medication updrs-ii...")
Do I Likely Qualify? — Self-Check Dimensions
The trial page offers an interactive self-check built from this trial's parsed criteria. It covers these dimensions; anything the criteria don't state clearly is answered "ask the study coordinator", never assumed.
- This trial appears to require an implanted or planned DBS device.
- This trial requires participants to be taking levodopa.
- This trial requires motor fluctuations (off periods).
- This trial requires dyskinesia (involuntary movements).
- This trial requires a MoCA thinking-test score of at least 24.
Locations
- University of California San Francisco, San Francisco, California, United States
Making Contact: How to Call This Study Site
Who to ask for
Ask for the study coordinator. Some sites call this person the research coordinator. They are the right person for questions about joining a study. If you reach a front desk or a doctor's office scheduler, ask them to connect you with the research team for this study.
What to say
It is fine to read this out loud, word for word:
Hello, my name is ____. I am calling about a Parkinson's study at your site. The study number is NCT07398157. It is the one about "Personalize brain stimulation for movement". Could I speak with the study coordinator about taking part?
If you are calling for a family member, use their name and mention that you help with their care.
What they will ask you
- The year of diagnosis
- Current medications and their doses
- Other health conditions
- Any procedures already done, such as deep brain stimulation (DBS)
- How far you are able to travel for study visits
- Whether a care partner can come to visits with you
What to have ready
- A written list of current medications and doses
- Your neurologist's name and phone number
- The diagnosis date. The year is enough.
- A recent visit summary from the neurologist, if you have one
What to ask them
- How many visits are there, and how long does each visit take?
- Is travel, parking, or my time reimbursed?
- Is there a placebo group, and what is my chance of being in it? The listing already answers this: This is a crossover trial: instead of staying in one group, you move through a sequence of assignments, so you receive the active treatment during at least one period of the study. Ask the coordinator for the exact sequence and how long each phase lasts.
- Would I need to stop or pause any of my current medications?
- What happens when the study ends? Could I stay on the treatment if it helps?
What to expect
- Expect to wait a few days for a callback. A week is common. Calling or emailing again after that is fine and normal.
- Many callers do not end up joining. Screening out is common and is not a judgment about you or your health.
- Asking questions commits you to nothing. You can stop the process at any point.
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Medtronic Percept Deep Brain Stimulation (cDBS). They are testing whether adding thin sensing electrodes under the scalp can let deep-brain stimulation adjust itself over a full 24 hours to reduce daytime off periods, troublesome dyskinesias, and sleep-related problems. The Medtronic Percept system records cortical rhythms from the subgaleal electrodes and runs closed-loop adaptive DBS that increases stimulation when brain signals predict an off state or motor symptoms and reduces stimulation during good on periods or sleep, so it is designed to work alongside levodopa rather than replace it. Adults 25 to 75 with idiopathic Parkinson's who are DBS candidates, have motor fluctuations despite optimized medications with at least two hours per day of off time or on time with dyskinesias, a normal brain MRI, and preserved cognition (MoCA 24 or higher) are being recruited. People with major medical or psychiatric risks, MR-incompatible implants, or other surgical contraindications are excluded, and about 24 participants will be enrolled.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- Being asked to pay to join a trial is a red flag: legitimate trials do not charge a participation fee, and the study treatment and study-specific tests are provided by the trial sponsor. What you might still pay depends on where you live: in the US, routine care you would receive anyway can be billed to you or your insurance; trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 3 years and 8 months.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- This is a crossover trial: instead of staying in one group, you move through a sequence of assignments, so you receive the active treatment during at least one period of the study. Ask the coordinator for the exact sequence and how long each phase lasts.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: Brain surgery / implanted device (invasive); Wearable / at-home monitoring (non-invasive); Questionnaires & surveys (non-invasive). Confirm the full schedule with the study coordinator.