Parkinson's Trial NCT07402928
Map dopamine signals for mood
- Trial ID
- NCT07402928
- Official Title
- Optimistic and Pessimistic Dopamine Signals in the Human Brain: a Mapping and Modelling Study in Health and Parkinson's Disease
- Goal
- Map dopamine signals for mood
- Status
- RECRUITING
- Sponsor
- Danish Research Centre for Magnetic Resonance
- Study Type
- OBSERVATIONAL
- Enrollment
- 140 participants
- Conditions
- Healthy, Parkinson, Medication Administration
Summary For Families
Goal: map and model how the brain's dopamine signals code "optimistic" versus "pessimistic" prediction errors during decision making, and compare those signals in people with Parkinson's to healthy adults. Approach: participants perform behavioral tasks while undergoing advanced magnetic resonance scans that track brain activity tied to dopamine-related signals, then researchers use computational models to separate optimistic from pessimistic responses; people with Parkinson's remain on their usual antiparkinsonian medication so the team sees patterns in the typical medicated state. Eligibility: adults 35 and older, either healthy volunteers or people with clinically established or probable akinetic-rigid Parkinson's who are on stable antiparkinsonian meds, not using advanced device therapies, and without MR contraindications, severe depression, or regular antipsychotic or GABAergic medication.
Locations
- Danish Research Centre for Magnetic Resonance (DRCMR), Hvidovre Hospital, Hvidovre, Denmark
Frequently Asked Questions
- What is this trial testing?
- This trial is studying an experimental treatment. Goal: map and model how the brain's dopamine signals code "optimistic" versus "pessimistic" prediction errors during decision making, and compare those signals in people with Parkinson's to healthy adults. Approach: participants perform behavioral tasks while undergoing advanced magnetic resonance scans that track brain activity tied to dopamine-related signals, then researchers use computational models to separate optimistic from pessimistic responses; people with Parkinson's remain on their usual antiparkinsonian medication so the team sees patterns in the typical medicated state. Eligibility: adults 35 and older, either healthy volunteers or people with clinically established or probable akinetic-rigid Parkinson's who are on stable antiparkinsonian meds, not using advanced device therapies, and without MR contraindications, severe depression, or regular antipsychotic or GABAergic medication.
- Who can participate?
- Participants must be at least 35 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- You are never charged a fee to join a legitimate clinical trial, and the study treatment and study-specific tests are provided by the trial sponsor at no charge. In the US, routine care you would receive anyway can still be billed to you or your insurance; coverage rules differ by country, and trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 2 years and 1 month.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- This is an observational study, so there is no placebo and no experimental treatment is assigned. Researchers observe and collect information while you continue your usual care.
- How many visits does this trial involve?
- Sub-study 1 requires one study day; sub-study 2 requires two study days.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: MRI scan (non-invasive). Confirm the full schedule with the study coordinator.