Reduce motor and neuropsychiatric fluctuations
- Trial ID
- NCT07404241
- Official Title
- Subthalamic and Cortical Electrophysiological Correlates of Motor and Neuropsychiatric Fluctuations in Parkinson's Disease
- Goal
- Reduce motor and neuropsychiatric fluctuations
- Status
- RECRUITING
- Sponsor
- University Hospital, Geneva
- Study Type
- OBSERVATIONAL
- Enrollment
- 30 participants
- Conditions
- PARKINSON DISEASE (Disorder)
Plain-Language Summary
The goal is to identify specific electrical brain signals in the subthalamic nucleus and cortex that line up with the motor and neuropsychiatric ups and downs people with Parkinson's often experience. To do that, researchers will record electrophysiological activity from the STN and cortical areas around the time of deep brain stimulation surgery using the implanted electrodes while participants are on dopaminergic medication, since levodopa changes brain rhythms and symptoms; STN-DBS normally treats motor fluctuations by delivering electrical pulses to the subthalamic nucleus to modulate abnormal circuits, and these recordings may show which signals drive motor or mood swings. Adults 18 to 80 with Parkinson's in the fluctuation stage who are candidates for STN-DBS or had STN-DBS implanted 4 to 8 weeks earlier, who are on dopaminergic therapy and do not have dementia, active psychosis, or other major unstable illnesses, can be enrolled.
Locations
- Geneva University Hospital, Geneva, Switzerland
Frequently Asked Questions
- What is this trial testing?
- This trial is studying an experimental treatment. The goal is to identify specific electrical brain signals in the subthalamic nucleus and cortex that line up with the motor and neuropsychiatric ups and downs people with Parkinson's often experience. To do that, researchers will record electrophysiological activity from the STN and cortical areas around the time of deep brain stimulation surgery using the implanted electrodes while participants are on dopaminergic medication, since levodopa changes brain rhythms and symptoms; STN-DBS normally treats motor fluctuations by delivering electrical pulses to the subthalamic nucleus to modulate abnormal circuits, and these recordings may show which signals drive motor or mood swings. Adults 18 to 80 with Parkinson's in the fluctuation stage who are candidates for STN-DBS or had STN-DBS implanted 4 to 8 weeks earlier, who are on dopaminergic therapy and do not have dementia, active psychosis, or other major unstable illnesses, can be enrolled.
- Who can participate?
- Participants must be between 18 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 2 years and 7 months.