Improve mood through caudate stimulation
- Trial ID
- NCT07409207
- Official Title
- Neurophysiology of Reward Signaling in Parkinson's Disease
- Goal
- Improve mood through caudate stimulation
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Vanderbilt University Medical Center
- Study Type
- INTERVENTIONAL
- Enrollment
- 75 participants
- Conditions
- Parkinson Disease
- Interventions
- Neurophysiology recordings, Neural stimulation
Plain-Language Summary
The goal is to map how reward signaling in the caudate is altered in Parkinson's, because those changes can affect motivation, decision making, and how people respond to treatments. During awake deep brain stimulation surgery at Vanderbilt, researchers will record electrical activity from the caudate and deliver brief, controlled neural stimulation while you do simple tasks, to see how reward circuits fire and react; those recordings can help guide better DBS targeting or future therapies. This work is observational and mapping-focused, not a new drug or long-term treatment. The study is for people age 40 and older with Parkinson's or another movement disorder who are already scheduled for DBS under local anesthesia with an electrode path that contacts the caudate, and who can follow instructions and speak English.
Locations
- Vanderbilt University Medical Center, Nashville, Tennessee, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Neurophysiology recordings. The goal is to map how reward signaling in the caudate is altered in Parkinson's, because those changes can affect motivation, decision making, and how people respond to treatments. During awake deep brain stimulation surgery at Vanderbilt, researchers will record electrical activity from the caudate and deliver brief, controlled neural stimulation while you do simple tasks, to see how reward circuits fire and react; those recordings can help guide better DBS targeting or future therapies. This work is observational and mapping-focused, not a new drug or long-term treatment. The study is for people age 40 and older with Parkinson's or another movement disorder who are already scheduled for DBS under local anesthesia with an electrode path that contacts the caudate, and who can follow instructions and speak English.
- Who can participate?
- Participants must be at least 40 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 5 years and 1 month.