Reduce tremor with focused ultrasound
- Trial ID
- NCT07417280
- Official Title
- Clinical Effects of Low-Intensity Focused Ultrasound Neuromodulation in Patients With Neurological and Psychiatric Disorders
- Goal
- Reduce tremor with focused ultrasound
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- University Health Network, Toronto
- Study Type
- INTERVENTIONAL
- Enrollment
- 50 participants
- Conditions
- Parkinson's Disease (PD), Essential Tremor, Orthostatic Tremor, Dystonia, Epilepsy, Substance Abuse Disorder, Deep Brain Stimulation
- Interventions
- LIFUS, Sham LIFUS
Plain-Language Summary
Low-intensity focused ultrasound, or LIFUS, is being tested to gently change the activity of the brain circuits that drive Parkinson's motor symptoms like tremor and stiffness, offering a noninvasive complement to medicines or surgery. The device sends focused sound waves through the skull to increase or decrease neuron firing in a targeted spot, it is compared with a sham procedure, and it does not deliver drugs so it can be used alongside levodopa or existing DBS rather than replacing them. Adults 18 to 85 with Parkinson's or other neurological or psychiatric conditions can enroll, but people with prior stroke, dementia or a MoCA under 22, certain implanted metal devices or pacemakers, pregnancy, major uncontrolled psychiatric illness, or serious systemic illness are excluded.
Locations
- Toronto Western Hospital, 399 Bathurst St, Toronto, Ontario, Canada
Frequently Asked Questions
- What is this trial testing?
- This trial is studying LIFUS. Low-intensity focused ultrasound, or LIFUS, is being tested to gently change the activity of the brain circuits that drive Parkinson's motor symptoms like tremor and stiffness, offering a noninvasive complement to medicines or surgery. The device sends focused sound waves through the skull to increase or decrease neuron firing in a targeted spot, it is compared with a sham procedure, and it does not deliver drugs so it can be used alongside levodopa or existing DBS rather than replacing them. Adults 18 to 85 with Parkinson's or other neurological or psychiatric conditions can enroll, but people with prior stroke, dementia or a MoCA under 22, certain implanted metal devices or pacemakers, pregnancy, major uncontrolled psychiatric illness, or serious systemic illness are excluded.
- Who can participate?
- Participants must be between 18 Years and 85 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 10 years and 1 month.