Improve language processing and behavior
- Trial ID
- NCT07449117
- Official Title
- Immediate Effects of Non-invasive Temporal Interference Stimulation Targeting Deep Fronto-Striatal Structures on Language Processing and Behavioral Performance in Patients With Neurodegenerative Diseases
- Goal
- Improve language processing and behavior
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Masaryk University
- Study Type
- INTERVENTIONAL
- Enrollment
- 70 participants
- Conditions
- Mild Cognitive Impairment (MCI) Amnestic, Lewy Body Disease With Mild Cognitive Impairment, Parkinson's Disease With Mild Cognitive Impairment
- Interventions
- Active Temporal Interference Stimulation (TIS), Placebo / Sham TIS
Plain-Language Summary
It aims to change activity in deep frontal and striatal brain circuits to produce immediate improvements in language processing and behavioral performance for people with mild cognitive impairment related to Parkinson's, Lewy body disease, or amnestic MCI. The approach, temporal interference stimulation, sends two high-frequency electrical currents through scalp electrodes that intersect deep in the brain to create a low-frequency modulation that can adjust neural firing in those targeted frontal and striatal areas. Participants receive either active TIS or a sham procedure so researchers can compare real versus placebo effects, and because TIS targets cognitive circuits it is not meant to replace or directly interact with dopaminergic drugs like levodopa. The study is looking for people aged 60 to 80 with MCI-PD, MCI-LB, or aMCI, and excludes those with severe psychiatric illness, other neurologic diseases, major head trauma, uncompensated medical or cancer conditions, or MRI-incompatible metal implants.
Locations
- CEITEC MU (Central European Institute of Technology, Masaryk University), Brno, South Moravian, Czechia
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Active Temporal Interference Stimulation (TIS). It aims to change activity in deep frontal and striatal brain circuits to produce immediate improvements in language processing and behavioral performance for people with mild cognitive impairment related to Parkinson's, Lewy body disease, or amnestic MCI. The approach, temporal interference stimulation, sends two high-frequency electrical currents through scalp electrodes that intersect deep in the brain to create a low-frequency modulation that can adjust neural firing in those targeted frontal and striatal areas. Participants receive either active TIS or a sham procedure so researchers can compare real versus placebo effects, and because TIS targets cognitive circuits it is not meant to replace or directly interact with dopaminergic drugs like levodopa. The study is looking for people aged 60 to 80 with MCI-PD, MCI-LB, or aMCI, and excludes those with severe psychiatric illness, other neurologic diseases, major head trauma, uncompensated medical or cancer conditions, or MRI-incompatible metal implants.
- Who can participate?
- Participants must be between 60 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 9 months.