Improve speech sequencing using stimulation
- Trial ID
- NCT07455760
- Official Title
- Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients
- Goal
- Improve speech sequencing using stimulation
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Boston University Charles River Campus
- Study Type
- INTERVENTIONAL
- Enrollment
- 80 participants
- Conditions
- Parkinson's Disease (PD), Essential Tremor
- Interventions
- Phoneme sequence learning, Cessation and re-enabling of stimulation of the STN, Cessation and re-enabling of stimulation of the VIM thalamic nucleus, Multisyllabic sequence learning
Plain-Language Summary
The goal is to figure out how the subthalamic and thalamic targets of deep brain stimulation help sequence sounds and syllables, so we can better understand why some people have speech problems with Parkinson's or essential tremor. Participants do phoneme and multisyllabic sequence learning tasks while researchers briefly stop and then re-enable stimulation of the subthalamic nucleus for Parkinson's or the ventral intermediate thalamus for essential tremor, and they record brain activity from Medtronic Percept implantable devices to link stimulation state with speech performance. Briefly stopping stimulation reduces the modulatory input those targets provide, which reveals their role in speech sequencing, and the study does not change your medication regimen. Eligible volunteers are native American English speakers age 18 or older with clinically established Parkinson's disease or essential tremor, stable meds and DBS settings for at least a month, a working STN or VIM DBS system with a Medtronic Percept PC or RC for sensing, intact hearing and cognition (MoCA ≥25), and the ability to tolerate short periods with DBS off; a few language backgrounds are excluded from one sub-study.
Locations
- Boston University, Boston, Massachusetts, United States
- Massachusetts General Hospital, Boston, Massachusetts, United States
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Phoneme sequence learning. The goal is to figure out how the subthalamic and thalamic targets of deep brain stimulation help sequence sounds and syllables, so we can better understand why some people have speech problems with Parkinson's or essential tremor. Participants do phoneme and multisyllabic sequence learning tasks while researchers briefly stop and then re-enable stimulation of the subthalamic nucleus for Parkinson's or the ventral intermediate thalamus for essential tremor, and they record brain activity from Medtronic Percept implantable devices to link stimulation state with speech performance. Briefly stopping stimulation reduces the modulatory input those targets provide, which reveals their role in speech sequencing, and the study does not change your medication regimen. Eligible volunteers are native American English speakers age 18 or older with clinically established Parkinson's disease or essential tremor, stable meds and DBS settings for at least a month, a working STN or VIM DBS system with a Medtronic Percept PC or RC for sensing, intact hearing and cognition (MoCA ≥25), and the ability to tolerate short periods with DBS off; a few language backgrounds are excluded from one sub-study.
- Who can participate?
- Participants must be at least 18 Years.
- Where is this trial located?
- This trial is recruiting at 2 locations.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 4 years and 5 months.