Reduce freezing episodes while walking
- Trial ID
- NCT07488026
- Official Title
- Effects of the Stimulation Site of Trans-spinal Magnetic Stimulation Combined With Transcranial Magnetic Stimulation on Functional Mobility in Individuals With Parkinson's Disease
- Goal
- Reduce freezing episodes while walking
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Universidade Federal de Pernambuco
- Study Type
- INTERVENTIONAL
- Enrollment
- 30 participants
- Conditions
- Parkinson's Disease (PD), Gait Disorders, Transcranial Magnetic Stimulation, Spinal Cord Stimulation
- Interventions
- Repetitive Transcranial Magnetic Stimulation, Cervical Trans-spinal Magnetic Stimulation, Thoracic Trans-spinal Magnetic Stimulation
Plain-Language Summary
Researchers want to see if pairing brain magnetic stimulation with magnetic pulses over the spinal cord can improve walking and reduce freezing episodes in people with mid-stage Parkinson's. The approach uses repetitive transcranial magnetic stimulation to modulate motor areas of the brain plus repetitive trans-spinal magnetic stimulation at either the cervical or thoracic level to directly activate spinal motor circuits, with the goal of improving timing and strength of leg muscle activity. Participants stay on their usual dopaminergic medications, so the stimulation is being tested as an add-on to, not a replacement for, levodopa or other Parkinson's drugs. The study enrolls adults 40 and older with neurologist-confirmed PD, Hoehn and Yahr stage 2.5,3, stable dopaminergic treatment for at least three months, at least one freezing-of-gait episode per week, and adequate cognition (MoCA ≥ 21); people with prior PD surgery, metal in the neck or spine, a history of seizures, or other conditions that affect walking are excluded.
Locations
- Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil
Frequently Asked Questions
- What is this trial testing?
- This trial is studying Repetitive Transcranial Magnetic Stimulation. Researchers want to see if pairing brain magnetic stimulation with magnetic pulses over the spinal cord can improve walking and reduce freezing episodes in people with mid-stage Parkinson's. The approach uses repetitive transcranial magnetic stimulation to modulate motor areas of the brain plus repetitive trans-spinal magnetic stimulation at either the cervical or thoracic level to directly activate spinal motor circuits, with the goal of improving timing and strength of leg muscle activity. Participants stay on their usual dopaminergic medications, so the stimulation is being tested as an add-on to, not a replacement for, levodopa or other Parkinson's drugs. The study enrolls adults 40 and older with neurologist-confirmed PD, Hoehn and Yahr stage 2.5,3, stable dopaminergic treatment for at least three months, at least one freezing-of-gait episode per week, and adequate cognition (MoCA ≥ 21); people with prior PD surgery, metal in the neck or spine, a history of seizures, or other conditions that affect walking are excluded.
- Who can participate?
- Participants must be at least 40 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- No. There is no cost to participate. Study-related care and treatment are provided at no charge.
- How long does the trial last?
- This trial is estimated to last approximately 10 months.