TMS for Parkinson's (NCT07570212)
Does brain stimulation ease movement
- Trial ID
- NCT07570212
- Official Title
- Exploration of the Efficacy of Individualized Transcranial Magnetic Stimulation in the Treatment of Parkinsonian Disorders
- Goal
- Does brain stimulation ease movement
- Phase
- NA
- Status
- RECRUITING
- Sponsor
- Peking University First Hospital
- Study Type
- INTERVENTIONAL
- Enrollment
- 50 participants
- Conditions
- Parkinson's Disease, Multiple System Atrophy, Progressive Supranuclear Palsy
- Interventions
- TMS
- Registry Record Last Updated
- 2026-06-29 (1 month ago)
- Estimated Commitment
- Lower commitment estimated from the protocol (based on: 10 study visits). This reflects time and procedures only — confirm details with the study coordinator.
Summary For Families
It aims to find out whether individualized, targeted repetitive transcranial magnetic stimulation can ease movement problems and other non-movement symptoms in people with parkinsonian disorders, and which symptoms respond and by how much. The approach uses a noninvasive machine that delivers focused magnetic pulses to brain areas chosen for each person using structural and functional magnetic resonance imaging, given in a rapid-pulse pattern called intermittent theta burst stimulation once daily for ten weekdays, with brain scans and electroencephalography before, after, and again 10 weeks later to track changes. Adults aged 30 to 80 with Parkinson's disease, multiple system atrophy, or progressive supranuclear palsy at moderate stages who can undergo magnetic resonance imaging and electroencephalography are eligible, provided they do not have metal implants, epilepsy, or ongoing brain stimulation therapies; medications and rehabilitation are kept stable during the two-week treatment.
Eligibility at a Glance
Key requirements found in this trial's official criteria, in plain language. Only what the listing states is shown; the study team makes the final call.
- Disease stage: Hoehn and Yahr stage 2 to 4
Do I Likely Qualify? — Self-Check Dimensions
The trial page offers an interactive self-check built from this trial's parsed criteria. It covers these dimensions; anything the criteria don't state clearly is answered "ask the study coordinator", never assumed.
- This trial enrolls people aged 30 to 80.
- This trial requires Hoehn and Yahr stage 2 to 4.
Locations
- Peking University First Hospital, Beijing, Beijing Municipality, China
Making Contact: How to Call This Study Site
Who to ask for
Ask for the study coordinator. Some sites call this person the research coordinator. They are the right person for questions about joining a study. If you reach a front desk or a doctor's office scheduler, ask them to connect you with the research team for this study.
What to say
It is fine to read this out loud, word for word:
Hello, my name is ____. I am calling about a Parkinson's study at your site. The study number is NCT07570212. It is the one about "Does brain stimulation ease movement". Could I speak with the study coordinator about taking part?
If you are calling for a family member, use their name and mention that you help with their care.
What they will ask you
- The year of diagnosis
- Current medications and their doses
- Other health conditions
- Any procedures already done, such as deep brain stimulation (DBS)
- How far you are able to travel for study visits
- Whether a care partner can come to visits with you
What to have ready
- A written list of current medications and doses
- Your neurologist's name and phone number
- The diagnosis date. The year is enough.
- A recent visit summary from the neurologist, if you have one
What to ask them
- How many visits are there, and how long does each visit take? The listing already answers this: There is a screening assessment, a 10-day (once-daily, Monday-Friday) treatment over 2 weeks, and follow-up assessments at the end of treatment and 10 weeks after treatment. Ask the coordinator to confirm it still applies.
- Is travel, parking, or my time reimbursed?
- Is there a placebo group, and what is my chance of being in it? The listing already answers this: Everyone in this trial receives the experimental treatment. There is no placebo group. Ask the coordinator to confirm it still applies.
- Would I need to stop or pause any of my current medications?
- What happens when the study ends? Could I stay on the treatment if it helps?
What to expect
- Expect to wait a few days for a callback. A week is common. Calling or emailing again after that is fine and normal.
- Many callers do not end up joining. Screening out is common and is not a judgment about you or your health.
- Asking questions commits you to nothing. You can stop the process at any point.
Frequently Asked Questions
- What is this trial testing?
- This trial is studying TMS. It aims to find out whether individualized, targeted repetitive transcranial magnetic stimulation can ease movement problems and other non-movement symptoms in people with parkinsonian disorders, and which symptoms respond and by how much. The approach uses a noninvasive machine that delivers focused magnetic pulses to brain areas chosen for each person using structural and functional magnetic resonance imaging, given in a rapid-pulse pattern called intermittent theta burst stimulation once daily for ten weekdays, with brain scans and electroencephalography before, after, and again 10 weeks later to track changes. Adults aged 30 to 80 with Parkinson's disease, multiple system atrophy, or progressive supranuclear palsy at moderate stages who can undergo magnetic resonance imaging and electroencephalography are eligible, provided they do not have metal implants, epilepsy, or ongoing brain stimulation therapies; medications and rehabilitation are kept stable during the two-week treatment.
- Who can participate?
- Participants must be between 30 Years and 80 Years.
- Where is this trial located?
- This trial is recruiting at 1 location.
- Does it cost anything to join?
- Being asked to pay to join a trial is a red flag: legitimate trials do not charge a participation fee, and the study treatment and study-specific tests are provided by the trial sponsor. What you might still pay depends on where you live: in the US, routine care you would receive anyway can be billed to you or your insurance; trials in the UK and Canada usually run through public health systems. Travel, parking, and time are real costs, and some trials reimburse them while others do not. Before enrolling, ask the study coordinator to explain in writing what is and is not covered.
- How long does the trial last?
- This trial is estimated to last approximately 1 year and 9 months.
- Can I leave the trial if I change my mind?
- Yes. You can withdraw from any clinical trial at any time, for any reason, without affecting your standard medical care. Trials are voluntary by law. The team may ask if you are willing to do a brief exit visit so they can collect safety information, but you are not obligated.
- Can my spouse or care partner come with me to visits?
- In most cases yes, and it is often encouraged. Care partners can help with notes, questions, and getting home safely after a long visit. Some study assessments do need to happen one on one, but care partners are usually welcome for the rest of the appointment.
- Will I get a placebo in this trial?
- Everyone in this trial receives the experimental treatment. There is no placebo group.
- How many visits does this trial involve?
- There is a screening assessment, a 10-day (once-daily, Monday-Friday) treatment over 2 weeks, and follow-up assessments at the end of treatment and 10 weeks after treatment.
- What procedures are involved in this trial?
- Based on the protocol, this trial involves: MRI scan (non-invasive); Brain wave recording (EEG) (non-invasive). Confirm the full schedule with the study coordinator.