Clinical Trials for People Not Yet on Parkinson's Medication
Some Parkinson's trials specifically enroll people who have not yet started medication — often called "levodopa-naïve", "treatment-naïve", or "untreated". Researchers look for this group because it lets them measure a new treatment's effect without the influence of existing Parkinson's drugs.
If you have recently been diagnosed and are still deciding when to begin treatment, these studies may be especially relevant. Taking part does not usually mean going without care — many trials still allow you to start standard medication if and when you need it.
Below are the recruiting trials we track that are open to people not yet on Parkinson's medication. Sign up to be emailed when a new one opens.
34 Recruiting Not Yet on Medication Trials
- Sound waves reduce movement stiffness, NCT07207122, RECRUITING
- Personalize brain stimulation for movement, NCT07398157, RECRUITING
- Find tests predicting Parkinson progression, NCT07533799, RECRUITING
- New medication improves brain energy, NCT07322887, PHASE2, RECRUITING
- Lemborexant improves motor and sleep, NCT07384429, PHASE4, RECRUITING
- Document motor complications despite medication, NCT07330258, RECRUITING
- Cell transplant improves motor symptoms, NCT07102342, PHASE1, PHASE2, RECRUITING
- Image brain cyclooxygenase related inflammation, NCT04396873, PHASE1, RECRUITING
- Improve cognition via resistance training, NCT04796506, RECRUITING
- Sensing brain stimulation lengthens sleep, NCT05070013, RECRUITING
- Test biophoton therapy for tremor, NCT06147999, RECRUITING
- Improve vision guided reaching ability, NCT05400499, RECRUITING
- Track early Parkinson disease progression, NCT05767151, RECRUITING
- Determine whether immunosuppression slows progression, NCT06834191, RECRUITING
- Surgery to reduce protein buildup, NCT06852352, RECRUITING
- Test new antibody slows progression, NCT06809400, PHASE1, RECRUITING
- Improve sleep using brain pulses, NCT07110376, RECRUITING
- Assess experimental pain in Parkinsons, NCT05981261, RECRUITING
- Increase walking endurance through exercise, NCT06088355, RECRUITING
- Map Parkinson brain immune activity, NCT05205291, RECRUITING
- Assess long term buntanetap safety, NCT07284784, PHASE2, PHASE3, RECRUITING
- Measure emotional response to music, NCT06688968, RECRUITING
- Improve attention memory and walking, NCT05968703, RECRUITING
- Brain stimulation improves motor control, NCT04799470, RECRUITING
- Improve balance using neurofeedback exergaming, NCT05986643, RECRUITING
- Reduce hallucinations without worsening movement, NCT04373317, PHASE4, RECRUITING
- Reduce freezing with dynamic cycling, NCT05298150, RECRUITING
- Detect Parkinson using gut biopsy, NCT05347407, RECRUITING
- Reduce medication wearing off fluctuations, NCT06928519, RECRUITING
- Identify motor plasticity affecting walking, NCT05286736, RECRUITING
- Test drug safety in Parkinson, NCT06466525, PHASE1, RECRUITING
- Improve sleep quality through exercise, NCT05644327, RECRUITING
- Improve insomnia with pallidal stimulation, NCT04116996, RECRUITING
- Identify early striatal metabolite changes, NCT04735172, RECRUITING